In vivo pharmacokinetic evaluation of carprofen delivery from intra-articular nanoparticles in rabbits: A population modelling approach
Osteoarthritis is treated with COX or fosfolipase A2 inhibitors such as carprofen, a propionic acid NSAID. The enhancement of its action over the articular cartilage is mandatory to facilitate its therapeutic application. Drug uptake into the cartilage requires high synovial fluid concentrations, an...
- Autores:
-
Parra-Coca, A.
Boix-Montañés, A.
Calpena-Campmany, A. C.
Colom, H.
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2021
- Institución:
- Universidad de Ciencias Aplicadas y Ambientales U.D.C.A
- Repositorio:
- Repositorio Institucional UDCA
- Idioma:
- eng
- OAI Identifier:
- oai:repository.udca.edu.co:11158/4203
- Acceso en línea:
- https://repository.udca.edu.co/handle/11158/4203
https://doi.org/10.1016/j.rvsc.2021.05.012
- Palabra clave:
- Intraarticular
Carprofeno
Farmacocinética
PLGA-P188 nanoparticles
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode.es