Diffusion Mechanism Modeling of Metformin in Human Organic Cationic Amino Acid Transporter one and Functional Impact of S189L, R206C, and G401S Mutation
Metformin used as a first-line drug to treat Type 2 Diabetes Mellitus is transported via organic cation channels to soft tissues. Mutations in the SLC22A1 gene, such as Gly401Ser, Ser189Leu, and Arg206Cys, may affect the drug’s therapeutic effect on these patients. This study aims at proposing a pot...
- Autores:
-
Cano Vásquez, Leydy Johana
Soto Ospina, Johnny Alejandro
Araque Marín, Pedronel
Caro Gómez, María Antonieta
Parra Marín, María Victoria
Bedoya Berrío, Gabriel de Jesús
Duque Vélez, Constanza Elena
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2021
- Institución:
- Tecnológico de Antioquia
- Repositorio:
- Repositorio Tdea
- Idioma:
- eng
- OAI Identifier:
- oai:dspace.tdea.edu.co:tdea/2747
- Acceso en línea:
- https://dspace.tdea.edu.co/handle/tdea/2747
- Palabra clave:
- Transport mechanism
Pharmacogenetics
Farmacogenética
Type 2 Diabetes
Diabetes Tipo 2
Metformin
Metformina
Structural biology
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by/4.0/