Modeling of Clavulanic Acid Production from Streptomyces clavuligerus using a Continuous Operation Mode

Clavulanic acid is a β-lactam inhibitor produced by fermentation with Streptomyces clavuligerus cells, and it is usually used to prevent resistance to certain antibiotics. However, CA production is limited at the bioreactor level due to its low performance. The latter generates expensive processes a...