Autoregressive modelling of chromatographic signals from urine samples for prostate cancer diagnosis
This article evaluates autoregressive modeling as a feature extraction method in a database of chromatographic signals from urine samples for non-invasive diagnostic support of prostate cancer in response to the research question: Can chromatographic signals from urine be characterized and used as a...
- Autores:
-
Soto Vergel, Angelo Joseph
Medina Delgado, Byron
palacios alvarado, wlamyr
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2021
- Institución:
- Universidad Francisco de Paula Santander
- Repositorio:
- Repositorio Digital UFPS
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.ufps.edu.co:ufps/6539
- Acceso en línea:
- https://repositorio.ufps.edu.co/handle/ufps/6539
- Palabra clave:
- Chromatography
Classification (of information)
Diagnosis
Diseases
Feature extraction
Noninvasive medical procedures
Signal processing
Urology
Auto regressive models
Autoregressive coefficient
Autoregressive modelling
Chromatographic signals
Feature extraction methods
Non-invasive diagnostics
Noninvasive methods
Research questions
Extraction
- Rights
- openAccess
- License
- Content from this work may be used under the terms of theCreative Commons Attribution 3.0 licence
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Autoregressive modelling of chromatographic signals from urine samples for prostate cancer diagnosis |
| title |
Autoregressive modelling of chromatographic signals from urine samples for prostate cancer diagnosis |
| spellingShingle |
Autoregressive modelling of chromatographic signals from urine samples for prostate cancer diagnosis Chromatography Classification (of information) Diagnosis Diseases Feature extraction Noninvasive medical procedures Signal processing Urology Auto regressive models Autoregressive coefficient Autoregressive modelling Chromatographic signals Feature extraction methods Non-invasive diagnostics Noninvasive methods Research questions Extraction |
| title_short |
Autoregressive modelling of chromatographic signals from urine samples for prostate cancer diagnosis |
| title_full |
Autoregressive modelling of chromatographic signals from urine samples for prostate cancer diagnosis |
| title_fullStr |
Autoregressive modelling of chromatographic signals from urine samples for prostate cancer diagnosis |
| title_full_unstemmed |
Autoregressive modelling of chromatographic signals from urine samples for prostate cancer diagnosis |
| title_sort |
Autoregressive modelling of chromatographic signals from urine samples for prostate cancer diagnosis |
| dc.creator.fl_str_mv |
Soto Vergel, Angelo Joseph Medina Delgado, Byron palacios alvarado, wlamyr |
| dc.contributor.author.none.fl_str_mv |
Soto Vergel, Angelo Joseph Medina Delgado, Byron palacios alvarado, wlamyr |
| dc.contributor.corporatename.spa.fl_str_mv |
Journal of Physics: Conference Series |
| dc.subject.proposal.eng.fl_str_mv |
Chromatography Classification (of information) Diagnosis Diseases Feature extraction Noninvasive medical procedures Signal processing Urology Auto regressive models Autoregressive coefficient Autoregressive modelling Chromatographic signals Feature extraction methods Non-invasive diagnostics Noninvasive methods Research questions Extraction |
| topic |
Chromatography Classification (of information) Diagnosis Diseases Feature extraction Noninvasive medical procedures Signal processing Urology Auto regressive models Autoregressive coefficient Autoregressive modelling Chromatographic signals Feature extraction methods Non-invasive diagnostics Noninvasive methods Research questions Extraction |
| description |
This article evaluates autoregressive modeling as a feature extraction method in a database of chromatographic signals from urine samples for non-invasive diagnostic support of prostate cancer in response to the research question: Can chromatographic signals from urine be characterized and used as a non-invasive method for cancer diagnosis? For this purpose, a database of 18 patients, 9 diagnosed with prostate cancer and 9 control patients, is consolidated, statistical methods are implemented to generate autoregressive coefficients from the data signals, and finally, the principal component analysis technique is applied for crossclass classification. As a result, a correct classification was obtained in the total number of samples validating the autoregressive modelling as a feature extraction method in contrast to the conventional methodology usually followed in chromatographic signal processing. |
| publishDate |
2021 |
| dc.date.issued.none.fl_str_mv |
2021-06-09 |
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2022-11-18T15:51:55Z |
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2022-11-18T15:51:55Z |
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Artículo de revista |
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10.1088/1742-6596/1938/1/012011 |
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eng |
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eng |
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Journal of Physics: Conference Series. Vol.1938 N°.1. (2021) |
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Vol. 1938 N°.1. (2021) |
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6 |
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1(2021) |
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1 |
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1938 |
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Soto-Vergel, A. J., Medina-Delgado, B., & Palacios-Alvarado, W. L. A. M. Y. R. (2021, May). Autoregressive modelling of chromatographic signals from urine samples for prostate cancer diagnosis. In Journal of Physics: Conference Series (Vol. 1938, No. 1, p. 012011). IOP Publishing. |
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Journal of Physics: Conference Series |
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Content from this work may be used under the terms of theCreative Commons Attribution 3.0 licence |
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Journal of Physics: Conference Series |
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Soto Vergel, Angelo Joseph0ba0e1be3cff1bc647809b1172ddd73b600Medina Delgado, Byron77a81f47bf20466c22fcea2d1e82a753600palacios alvarado, wlamyr735190501fdb6e5d51e2f4cc4e5b66ec600Journal of Physics: Conference Series2022-11-18T15:51:55Z2022-11-18T15:51:55Z2021-06-09https://repositorio.ufps.edu.co/handle/ufps/653910.1088/1742-6596/1938/1/012011This article evaluates autoregressive modeling as a feature extraction method in a database of chromatographic signals from urine samples for non-invasive diagnostic support of prostate cancer in response to the research question: Can chromatographic signals from urine be characterized and used as a non-invasive method for cancer diagnosis? For this purpose, a database of 18 patients, 9 diagnosed with prostate cancer and 9 control patients, is consolidated, statistical methods are implemented to generate autoregressive coefficients from the data signals, and finally, the principal component analysis technique is applied for crossclass classification. As a result, a correct classification was obtained in the total number of samples validating the autoregressive modelling as a feature extraction method in contrast to the conventional methodology usually followed in chromatographic signal processing.07 páginasapplication/pdfengJournal of Physics: Conference SeriesReino UnidoJournal of Physics: Conference Series. Vol.1938 N°.1. (2021)Vol. 1938 N°.1. (2021)61(2021)11938Soto-Vergel, A. J., Medina-Delgado, B., & Palacios-Alvarado, W. L. A. M. Y. R. (2021, May). Autoregressive modelling of chromatographic signals from urine samples for prostate cancer diagnosis. In Journal of Physics: Conference Series (Vol. 1938, No. 1, p. 012011). IOP Publishing.Journal of Physics: Conference SeriesContent from this work may be used under the terms of theCreative Commons Attribution 3.0 licencehttps://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2https://iopscience.iop.org/article/10.1088/1742-6596/1938/1/012011/pdfAutoregressive modelling of chromatographic signals from urine samples for prostate cancer diagnosisArtículo de revistahttp://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85ChromatographyClassification (of information)DiagnosisDiseasesFeature extractionNoninvasive medical proceduresSignal processingUrologyAuto regressive modelsAutoregressive coefficientAutoregressive modellingChromatographic signalsFeature extraction methodsNon-invasive diagnosticsNoninvasive methodsResearch questionsExtractionSerrano N, Cetó X, Núñez O, Aragó M, Gámez A, Ariño C, Díaz J 2018 Characterization and classification of Spanish paprika (Capsicum annuum L) by liquid chromatography coupled to electrochemical detection with screen-printed carbon-based nanomaterials electrodes Talanta 189(1) 296Merchak N, Rizk T, Silvestre V, Remaud G, Bejjani J, Akoka S 2018 Olive oil characterization and classification by 13C NMR with a polarization transfer technique: a comparison with gas chromatography and 1H NMR Food Chem. 245(1) 717Tao Y, Huang S, Yan J, Cai B 2019 Determination of major components from Radix Achyranthes bidentate using ultra high-performance liquid chromatography with triple quadrupole tandem mass spectrometry and an evaluation of their anti‐osteoporosis effect in vitro J. Sep. Sci. 42(13) 2214Zhang J, Zheng C, Xia Y, Wang B, Chen P 2017 Optimization enhanced genetic algorithm-support vector regression for the prediction of compound retention indices in gas chromatography Neurocomputing 240(1) 183Allen-Zhu Z, Li Y, Liang Y 2019 Learning and generalization in overparameterized neural networks, going beyond two layers 33rd Conference on Neural Information Processing Systems (Canada: NeurIPS)Soto-Vergel A, Mendoza L, Delgado B 2019 Analysis of energy and major components in chromatographic signals for the diagnosis of prostate cancer Respuestas 24(1) 76Yang J, Lee J, Byeon S, Rha K, Moon M 2017 Size dependent lipidomic analysis of urinary exosomes from patients with prostate cancer by flow field-flow fractionation and nanoflow liquid chromatographytandem mass spectrometry Analytical Chemistry 89(4) 2488Rohrbach D, Mamou J 2018 Autoregressive signal processing applied to high-frequency acoustic microscopy of soft tissues IEEE Transaction on Ultrasonic, Ferroelectric, Frequency Control 65(11) 2054Büyükkabasakal K, Acikbas S, Deniz A, Acikbas Y, Capan R, Erdogan M 2019 Chemical sensor properties and mathematical modeling of graphene oxide langmuir-blodgett thin films IEEE Sens. J. 19(20) 9097Chen G, Gan M, Chen G 2018 Generalized exponential autoregressive models for nonlinear time series: stationarity, estimation, and applications J. Inf. Sci. 438(1) 46Kumar K 2018 Optimizing the process of reference selection for correlation optimised warping (COW) and interval correlation shifting (icoshift) analysis: automating the chromatographic alignment procedure Anal. Methods 10(2) 190Ottensmann M, Stoffel M, Nichols H, Hoffman J 2018 GCalignR: An R package for aligning gaschromatography data for ecological and evolutionary studies PloS one 13(6) 1Wu H, Zhou Y, Yang C, Zhu H, Hao D, Ren S 2020 A method of prediction for transformer malfunction based on oil chromatography 5th International Conference on Automation, Control and Robotics Engineering (China: IEEE) p 444Patiño-Domínguez B 2016 Determinación de Parámetros Operacionales Necesarios en el Empaquetado de Columnas deCcromatografía (España: Universidad da Coruña)Cazes J 2010 Encyclopedia of Chromatography (New York: CRC Press)Cavanaugh J, Neath A 2019 The Akaike information criterion: background, derivation, properties, application, interpretation, and refinements Wiley Interdiscip. Rev. Comput. Stat. 11(3) e1460Gupta V, Mittal M 2019 R-Peak detection in ECG signal using Yule–Walker and principal component analysis IETE Journal of Research 1Libal U, Johansson K 2019 Yule-Walker equations using higher order statistics for nonlinear autoregressive model Signal Processing Symposium (Polonia: IEEE)Franses P, Janssens E 2019 Spurious principal components Appl. Econ. Lett 26(1) 37Li Z, et al. 2020 Optimization of SEMG classification model based on correlation analysis and feature Selection 5th International Conference on Advanced Robotics and Mechatronics (China: IEEE) p 402ORIGINALSoto-Vergel_2021_J._Phys.__Conf._Ser._1938_012011.pdfSoto-Vergel_2021_J._Phys.__Conf._Ser._1938_012011.pdfapplication/pdf651985https://repositorio.ufps.edu.co/bitstream/ufps/6539/1/Soto-Vergel_2021_J._Phys.__Conf._Ser._1938_012011.pdf6fcf0146d9f084919b662555c39175b1MD51open accessLICENSElicense.txtlicense.txttext/plain; charset=utf-814828https://repositorio.ufps.edu.co/bitstream/ufps/6539/2/license.txt2f9959eaf5b71fae44bbf9ec84150c7aMD52open accessTEXTSoto-Vergel_2021_J._Phys.__Conf._Ser._1938_012011.pdf.txtSoto-Vergel_2021_J._Phys.__Conf._Ser._1938_012011.pdf.txtExtracted texttext/plain21025https://repositorio.ufps.edu.co/bitstream/ufps/6539/3/Soto-Vergel_2021_J._Phys.__Conf._Ser._1938_012011.pdf.txt4fe063cc1bff398307cfdad8aaf556e7MD53open 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 incorporada en las Obras Colectivas.

b.	Distribuir copias o fonogramas de las Obras, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública, incluyéndolas como incorporadas en Obras Colectivas, según corresponda.

c.	Distribuir copias de las Obras Derivadas que se generen, exhibirlas públicamente, ejecutarlas públicamente y/o ponerlas a disposición pública.
Los derechos mencionados anteriormente pueden ser ejercidos en todos los medios y formatos, actualmente conocidos o que se inventen en el futuro. Los derechos antes mencionados incluyen el derecho a realizar dichas modificaciones en la medida que sean técnicamente necesarias para ejercer los derechos en otro medio o formatos, pero de otra manera usted no está autorizado para realizar obras derivadas. Todos los derechos no otorgados expresamente por el Licenciante quedan por este medio reservados, incluyendo pero sin limitarse a aquellos que se mencionan en las secciones 4(d) y 4(e).

4. Restricciones.
La licencia otorgada en la anterior Sección 3 está expresamente sujeta y limitada por las siguientes restricciones:

a.	Usted puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra sólo bajo las condiciones de esta Licencia, y Usted debe incluir una copia de esta licencia o del Identificador Universal de Recursos de la misma con cada copia de la Obra que distribuya, exhiba públicamente, ejecute públicamente o ponga a disposición pública. No es posible ofrecer o imponer ninguna condición sobre la Obra que altere o limite las condiciones de esta Licencia o el ejercicio de los derechos de los destinatarios otorgados en este documento. No es posible sublicenciar la Obra. Usted debe mantener intactos todos los avisos que hagan referencia a esta Licencia y a la cláusula de limitación de garantías. Usted no puede distribuir, exhibir públicamente, ejecutar públicamente, o poner a disposición pública la Obra con alguna medida tecnológica que controle el acceso o la utilización de ella de una forma que sea inconsistente con las condiciones de esta Licencia. Lo anterior se aplica a la Obra incorporada a una Obra Colectiva, pero esto no exige que la Obra Colectiva aparte de la obra misma quede sujeta a las condiciones de esta Licencia. Si Usted crea una Obra Colectiva, previo aviso de cualquier Licenciante debe, en la medida de lo posible, eliminar de la Obra Colectiva cualquier referencia a dicho Licenciante o al Autor Original, según lo solicitado por el Licenciante y conforme lo exige la cláusula 4(c).

b.	Usted no puede ejercer ninguno de los derechos que le han sido otorgados en la Sección 3 precedente de modo que estén principalmente destinados o directamente dirigidos a conseguir un provecho comercial o una compensación monetaria privada. El intercambio de la Obra por otras obras protegidas por derechos de autor, ya sea a través de un sistema para compartir archivos digitales (digital file-sharing) o de cualquier otra manera no será considerado como estar destinado principalmente o dirigido directamente a conseguir un provecho comercial o una compensación monetaria privada, siempre que no se realice un pago mediante una compensación monetaria en relación con el intercambio de obras protegidas por el derecho de autor.

c.	Si usted distribuye, exhibe públicamente, ejecuta públicamente o ejecuta públicamente en forma digital la Obra o cualquier Obra Derivada u Obra Colectiva, Usted debe mantener intacta toda la información de derecho de autor de la Obra y proporcionar, de forma razonable según el medio o manera que Usted esté utilizando: (i) el nombre del Autor Original si está provisto (o seudónimo, si fuere aplicable), y/o (ii) el nombre de la parte o las partes que el Autor Original y/o el Licenciante hubieren designado para la atribución (v.g., un instituto patrocinador, editorial, publicación) en la información de los derechos de autor del Licenciante, términos de servicios o de otras formas razonables; el título de la Obra si está provisto; en la medida de lo razonablemente factible y, si está provisto, el Identificador Uniforme de Recursos (Uniform Resource Identifier) que el Licenciante especifica para ser asociado con la Obra, salvo que tal URI no se refiera a la nota sobre los derechos de autor o a la información sobre el licenciamiento de la Obra; y en el caso de una Obra Derivada, atribuir el crédito identificando el uso de la Obra en la Obra Derivada (v.g., "Traducción Francesa de la Obra del Autor Original," o "Guión Cinematográfico basado en la Obra original del Autor Original"). Tal crédito puede ser implementado de cualquier forma razonable; en el caso, sin embargo, de Obras Derivadas u Obras Colectivas, tal crédito aparecerá, como mínimo, donde aparece el crédito de cualquier otro autor comparable y de una manera, al menos, tan destacada como el crédito de otro autor comparable.

d.	Para evitar toda confusión, el Licenciante aclara que, cuando la obra es una composición musical:

i.	Regalías por interpretación y ejecución bajo licencias generales. El Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública o la ejecución pública digital de la obra y de recolectar, sea individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, SAYCO), las regalías por la ejecución pública o por la ejecución pública digital de la obra (por ejemplo Webcast) licenciada bajo licencias generales, si la interpretación o ejecución de la obra está primordialmente orientada por o dirigida a la obtención de una ventaja comercial o una compensación monetaria privada.

ii.	Regalías por Fonogramas. El Licenciante se reserva el derecho exclusivo de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, los consagrados por la SAYCO), una agencia de derechos musicales o algún agente designado, las regalías por cualquier fonograma que Usted cree a partir de la obra (“versión cover”) y distribuya, en los términos del régimen de derechos de autor, si la creación o distribución de esa versión cover está primordialmente destinada o dirigida a obtener una ventaja comercial o una compensación monetaria privada.

e.	Gestión de Derechos de Autor sobre Interpretaciones y Ejecuciones Digitales (WebCasting). Para evitar toda confusión, el Licenciante aclara que, cuando la obra sea un fonograma, el Licenciante se reserva el derecho exclusivo de autorizar la ejecución pública digital de la obra (por ejemplo, webcast) y de recolectar, individualmente o a través de una sociedad de gestión colectiva de derechos de autor y derechos conexos (por ejemplo, ACINPRO), las regalías por la ejecución pública digital de la obra (por ejemplo, webcast), sujeta a las disposiciones aplicables del régimen de Derecho de Autor, si esta ejecución pública digital está primordialmente dirigida a obtener una ventaja comercial o una compensación monetaria privada.

5. Representaciones, Garantías y Limitaciones de Responsabilidad.
A MENOS QUE LAS PARTES LO ACORDARAN DE OTRA FORMA POR ESCRITO, EL LICENCIANTE OFRECE LA OBRA (EN EL ESTADO EN EL QUE SE ENCUENTRA) “TAL CUAL”, SIN BRINDAR GARANTÍAS DE CLASE ALGUNA RESPECTO DE LA OBRA, YA SEA EXPRESA, IMPLÍCITA, LEGAL O CUALQUIERA OTRA, INCLUYENDO, SIN LIMITARSE A ELLAS, GARANTÍAS DE TITULARIDAD, COMERCIABILIDAD, ADAPTABILIDAD O ADECUACIÓN A PROPÓSITO DETERMINADO, AUSENCIA DE INFRACCIÓN, DE AUSENCIA DE DEFECTOS LATENTES O DE OTRO TIPO, O LA PRESENCIA O AUSENCIA DE ERRORES, SEAN O NO DESCUBRIBLES (PUEDAN O NO SER ESTOS DESCUBIERTOS). ALGUNAS JURISDICCIONES NO PERMITEN LA EXCLUSIÓN DE GARANTÍAS IMPLÍCITAS, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.

6. Limitación de responsabilidad.
A MENOS QUE LO EXIJA EXPRESAMENTE LA LEY APLICABLE, EL LICENCIANTE NO SERÁ RESPONSABLE ANTE USTED POR DAÑO ALGUNO, SEA POR RESPONSABILIDAD EXTRACONTRACTUAL, PRECONTRACTUAL O CONTRACTUAL, OBJETIVA O SUBJETIVA, SE TRATE DE DAÑOS MORALES O PATRIMONIALES, DIRECTOS O INDIRECTOS, PREVISTOS O IMPREVISTOS PRODUCIDOS POR EL USO DE ESTA LICENCIA O DE LA OBRA, AUN CUANDO EL LICENCIANTE HAYA SIDO ADVERTIDO DE LA POSIBILIDAD DE DICHOS DAÑOS. ALGUNAS LEYES NO PERMITEN LA EXCLUSIÓN DE CIERTA RESPONSABILIDAD, EN CUYO CASO ESTA EXCLUSIÓN PUEDE NO APLICARSE A USTED.

7. Término.

a.	Esta Licencia y los derechos otorgados en virtud de ella terminarán automáticamente si Usted infringe alguna condición establecida en ella. Sin embargo, los individuos o entidades que han recibido Obras Derivadas o Colectivas de Usted de conformidad con esta Licencia, no verán terminadas sus licencias, siempre que estos individuos o entidades sigan cumpliendo íntegramente las condiciones de estas licencias. Las Secciones 1, 2, 5, 6, 7, y 8 subsistirán a cualquier terminación de esta Licencia.

b.	Sujeta a las condiciones y términos anteriores, la licencia otorgada aquí es perpetua (durante el período de vigencia de los derechos de autor de la obra). No obstante lo anterior, el Licenciante se reserva el derecho a publicar y/o estrenar la Obra bajo condiciones de licencia diferentes o a dejar de distribuirla en los términos de esta Licencia en cualquier momento; en el entendido, sin embargo, que esa elección no servirá para revocar esta licencia o que deba ser otorgada , bajo los términos de esta licencia), y esta licencia continuará en pleno vigor y efecto a menos que sea terminada como se expresa atrás. La Licencia revocada continuará siendo plenamente vigente y efectiva si no se le da término en las condiciones indicadas anteriormente.

8. Varios.

a.	Cada vez que Usted distribuya o ponga a disposición pública la Obra o una Obra Colectiva, el Licenciante ofrecerá al destinatario una licencia en los mismos términos y condiciones que la licencia otorgada a Usted bajo esta Licencia.

b.	Si alguna disposición de esta Licencia resulta invalidada o no exigible, según la legislación vigente, esto no afectará ni la validez ni la aplicabilidad del resto de condiciones de esta Licencia y, sin acción adicional por parte de los sujetos de este acuerdo, aquélla se entenderá reformada lo mínimo necesario para hacer que dicha disposición sea válida y exigible.

c.	Ningún término o disposición de esta Licencia se estimará renunciada y ninguna violación de ella será consentida a menos que esa renuncia o consentimiento sea otorgado por escrito y firmado por la parte que renuncie o consienta.

d.	Esta Licencia refleja el acuerdo pleno entre las partes respecto a la Obra aquí licenciada. No hay arreglos, acuerdos o declaraciones respecto a la Obra que no estén especificados en este documento. El Licenciante no se verá limitado por ninguna disposición adicional que pueda surgir en alguna comunicación emanada de Usted. Esta Licencia no puede ser modificada sin el consentimiento mutuo por escrito del Licenciante y Usted.
0000-0001-5093-01830ba0e1be3cff1bc647809b1172ddd73b6000000-0003-0754-862977a81f47bf20466c22fcea2d1e82a753600 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