A Direct Role for the CD1b Endogenous Spacer in the Recognition of a Mycobacterium tuberculosis Antigen by T-Cell Receptors

Lipids, glycolipids and lipopeptides derived from Mycobacterium tuberculosis (Mtb) are presented to T cells by monomorphic molecules known as CD1. This is the case of the Mtb-specific sulfoglycolipid Ac2SGL, which is presented by CD1b molecules and is recognized by T cells found in tuberculosis (TB)...

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Autores:

Tipo de recurso:

Fecha de publicación:

2020

Institución:

Universidad de Medellín

Repositorio:

Repositorio UDEM

Idioma:

eng

OAI Identifier:

oai:repository.udem.edu.co:11407/5906

Acceso en línea:

http://hdl.handle.net/11407/5906

Palabra clave:

Ac2SGL
CD1b
endogenous spacer
Mycobacterium tuberculosis
scTCR
sulfoglycolipids
amino acid
CD1b antigen
glucose
glucose monomycolate
Mycobacterium antigen
sulfuric acid
T lymphocyte receptor
unclassified drug
Article
crystal structure
enzyme linked immunosorbent assay
human
hypothesis
light chain
molecular docking
Mycobacterium tuberculosis
protein lipid interaction
protein structure
T lymphocyte
tuberculosis

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