Dofetilide effect on human atrial action potential under normal and atrial fibrillation conditions. In silico study

Atrial fibrillation is the most common sustained cardiac arrhythmia. Dofetilide is an antiarrhythmic drug for the treatment of chronic AF that specifically blocks the rapid component of the delayed rectifier potassium current IKr. Dofetilide prolongs the action potential duration and QT interval in...

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Autores:

Tipo de recurso:

Fecha de publicación:

2017

Institución:

Universidad de Medellín

Repositorio:

Repositorio UDEM

Idioma:

eng

OAI Identifier:

oai:repository.udem.edu.co:11407/4275

Acceso en línea:

http://hdl.handle.net/11407/4275

Palabra clave:

Antiarrhythmic drug
Atrial fibrillation
Dofetilide
In silico model
Biomedical engineering
Electric rectifiers
Electrophysiology
Action potential durations
Antiarrhythmic drug
Atrial fibrillation
Cardiac arrhythmia
Concentration-dependent
Dofetilide
In-silico models
Potassium currents
Diseases

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http://purl.org/coar/access_right/c_16ec