The antimalarial chloroquine reduces the burden of persistent atrial fibrillation

In clinical practice, reducing the burden of persistent atrial fibrillation by pharmacological means is challenging. We explored if blocking the background and the acetylcholine-activated inward rectifier potassium currents (IK1 and IKACh) could be antiarrhythmic in persistent atrial fibrillation. W...

Full description

Autores:

Tipo de recurso:

Fecha de publicación:

2019

Institución:

Universidad de Medellín

Repositorio:

Repositorio UDEM

Idioma:

eng

OAI Identifier:

oai:repository.udem.edu.co:11407/5701

Acceso en línea:

http://hdl.handle.net/11407/5701

Palabra clave:

Chloroquine
IK1
IKACh
Persistent atrial fibrillation
Potassium inward rectifiers
antimalarial agent
apixaban
chloroquine
inwardly rectifying potassium channel subunit Kir2.1
inwardly rectifying potassium channel subunit Kir3.1
metoprolol
potassium channel
unclassified drug
action potential duration
aged
amebiasis
Article
clinical article
disease burden
drug effect
drug mechanism
drug protein binding
female
human
IC50
laboratory test
mathematical model
molecular docking
molecular model
patch clamp technique
persistent atrial fibrillation
potassium current

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http://purl.org/coar/access_right/c_16ec