Lead (Pb++) effect on human atrial action potential under normal and atrial fibrillation conditions. In silico study

Lead (Pb++) is a toxic agent that can exert adverse effects on the cardiac human health. Pb++ blocks the Ltype Ca++ channels. A decrease in L-type calcium current (ICaL) is an important mechanism favoring atrial fibrillation. It is important to study the electrophysiological Pb++ effects on the atrial action potential in healthy people and those with AF. For this, we study the consequences of Pb++ on action potential, under normal and atrial fibrillation condition using in silico models. Our results suggest that Pb++ blocks ICaL current in a fraction greater as the concentration increases, resulting in an action potential duration shortening, Pb++ has a greater action potential duration effect on control conditions. To our knowledge, this is the first work that has developed mathematical models of Pb++ effect on ICaLcurrent to study its effect on human atrial action potential. © Springer Nature Singapore Pte Ltd. 2017.

• Fecha de publicación: 2017
• Institución: Universidad de Medellín
• Repositorio: Repositorio UDEM
• Idioma: eng
• OAI Identifier: oai:repository.udem.edu.co:11407/4263
• Acceso en línea: http://hdl.handle.net/11407/4263
• Palabra clave: Atrial fibrillation; In silico models; L-type Ca++ current; Lead (Pb++); Biomedical engineering; Calcium; Diseases; Electrophysiology; Action potential durations; Action potentials; Adverse effect; Atrial fibrillation; Calcium current; Healthy people; In-silico models; Toxic agents; Lead
• License: http://purl.org/coar/access_right/c_16ec