Lead and carbon monoxide effects on human atrial action potential. In silico study
Exposure to air pollutants like lead (Pb++) and carbon monoxide (CO), promotes the occurrence of cardiovascular diseases. Experimental studies have shown that Pb++ and CO block the L-type calcium channels, decreasing the calcium current (ICaL) and the action potential duration (APD), favoring the in...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2017
- Institución:
- Universidad de Medellín
- Repositorio:
- Repositorio UDEM
- Idioma:
- eng
- OAI Identifier:
- oai:repository.udem.edu.co:11407/4914
- Acceso en línea:
- http://hdl.handle.net/11407/4914
- Palabra clave:
- Air pollution
Calcium
Calcium compounds
Carbon monoxide
Cardiology
Action potential durations
Action potentials
Atrial arrhythmia
Calcium current
Cardio-vascular disease
Combined effect
Computational simulation
L-type calcium channels
Lead compounds
- Rights
- License
- http://purl.org/coar/access_right/c_16ec
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Lead and carbon monoxide effects on human atrial action potential. In silico study |
| title |
Lead and carbon monoxide effects on human atrial action potential. In silico study |
| spellingShingle |
Lead and carbon monoxide effects on human atrial action potential. In silico study Air pollution Calcium Calcium compounds Carbon monoxide Cardiology Action potential durations Action potentials Atrial arrhythmia Calcium current Cardio-vascular disease Combined effect Computational simulation L-type calcium channels Lead compounds |
| title_short |
Lead and carbon monoxide effects on human atrial action potential. In silico study |
| title_full |
Lead and carbon monoxide effects on human atrial action potential. In silico study |
| title_fullStr |
Lead and carbon monoxide effects on human atrial action potential. In silico study |
| title_full_unstemmed |
Lead and carbon monoxide effects on human atrial action potential. In silico study |
| title_sort |
Lead and carbon monoxide effects on human atrial action potential. In silico study |
| dc.contributor.affiliation.spa.fl_str_mv |
Tobón, C., Universidad de Medellín;Pachajoa, D.C., Instituto Tecnológico Metropolitano;Ugarte, J.P., Universidad de San Buenaventura;Orozco-Duque, A., Instituto Tecnológico Metropolitano;Saiz, J., Universitat Politècnica de València |
| dc.subject.spa.fl_str_mv |
Air pollution Calcium Calcium compounds Carbon monoxide Cardiology Action potential durations Action potentials Atrial arrhythmia Calcium current Cardio-vascular disease Combined effect Computational simulation L-type calcium channels Lead compounds |
| topic |
Air pollution Calcium Calcium compounds Carbon monoxide Cardiology Action potential durations Action potentials Atrial arrhythmia Calcium current Cardio-vascular disease Combined effect Computational simulation L-type calcium channels Lead compounds |
| description |
Exposure to air pollutants like lead (Pb++) and carbon monoxide (CO), promotes the occurrence of cardiovascular diseases. Experimental studies have shown that Pb++ and CO block the L-type calcium channels, decreasing the calcium current (ICaL) and the action potential duration (APD), favoring the initiation of atrial arrhythmias. Our goal is to study the effects of Pb++ and CO at different concentrations, on ICaL and action potential using computational simulation. For this, we developed mathematical models of the air pollutants effects on the atrial L-type calcium channel and they were incorporated in a mathematical model of human atrial cell and in a 2D model of atrial tissue. Our results suggest that the Pb++ and CO block the ICaL current in a fraction that increases as the concentration increases, generating an APD shortening. The combined effect of both air pollutants generated an APD shortening and a stable rotor, which is considered as a pro-arrhythmic effect. These results are consistent with experimental studies. In silico studies may contribute to a better understanding of the mechanisms by which air pollutants have unhealthy effects on cardiac system. © 2017 IEEE Computer Society. All rights reserved. |
| publishDate |
2017 |
| dc.date.created.none.fl_str_mv |
2017 |
| dc.date.accessioned.none.fl_str_mv |
2018-10-31T13:44:24Z |
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2018-10-31T13:44:24Z |
| dc.type.eng.fl_str_mv |
Conference Paper |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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http://purl.org/coar/resource_type/c_c94f |
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info:eu-repo/semantics/conferenceObject |
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23258861 |
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http://hdl.handle.net/11407/4914 |
| dc.identifier.doi.none.fl_str_mv |
10.22489/CinC.2017.123-037 |
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23258861 10.22489/CinC.2017.123-037 |
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http://hdl.handle.net/11407/4914 |
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eng |
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eng |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85045124430&doi=10.22489%2fCinC.2017.123-037&partnerID=40&md5=fe262767368ee1e80a222bc4e723bae5 |
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44 |
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1 |
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4 |
| dc.relation.ispartofes.spa.fl_str_mv |
Computing in Cardiology |
| dc.relation.references.spa.fl_str_mv |
The cost of air pollution (2014) Health Impacts of Road Transport, pp. 1-80. , OECD OECD Publishing;National ambient air quality standards (NAAQS) | air and radiation | US EPA (2012) US Environ Prot Agency, off Air Qual Plan Stand, (4), pp. 2014-2015;(2016) Lead Poisoning and Health [Internet], , http://www.who.int/mediacentre/factsheets/fs379/en, World Health Organization;Henry, C.R., Satran, D., Lindgren, B., Adkinson, C., Nicholson, C.I., Henry, T.D., Myocardial injury and long-term mortality following moderate to severe carbon monoxide poisoning (2006) Am Med Assoc., 295 (4), pp. 398-402;Bhatnagar, A., Cardiovascular pathophysiology of environmental pollutants (2004) Am J Physiol Heart Circ Physiol, 286 (2), pp. H479-H485;Prentice, R., Kopp, S., Cardiotoxicity of lead at various perfusate calcium concentrations: Functional and metabolic responses of the perfused rat heart (1985) Toxicol Appl Pharmacol, 81, pp. 491-501;Ansari, M.A., Maayah, Z.H., Bakheet, S.A., El-Kadi, A.O., Korashy, H., The role of aryl hydrocarbon receptor signaling pathway in cardiotoxicity of acute lead intoxication in vivo and in vitro rat model (2013) Toxicology, 306, pp. 40-49;Samoli, E., Touloumi, G., Schwartz, J., Anderson, H.R., Schindler, C., Forsberg, B., Short-term effects of carbon monoxide on mortality: An analysis within the APHEA project (2007) Environ Health Perspect, 115 (11), pp. 1578-1583;Dales, R., Ambient carbon monoxide May influence heart rate variability in subjects with coronary artery disease (2004) Occup Env Med., 46 (12), pp. 1217-1221;Simkhovich, B.Z., Kleinman, M.T., Kloner, R.A., Air pollution and cardiovascular injury. Epidemiology, toxicology, and mechanisms (2008) Journal of the American College of Cardiology, 52 (9), pp. 719-726;(2013) Integrated Science Assessment (ISA) for Lead, , U.S. EPA Final Report, Jul Washington;2013;Bernal, J., Lee, J., Cribbs, L.L., Perezreyes, E., (1997) Full Reversal of Pb++ Block of L-Type Ca++ Channels Requires Treatment With Heavy Metal Antidotes1, 282 (1), pp. 172-180;Dinanian, S., Boixel, C., Juin, C., Hulot, J.-S., Coulombe, A., Rücker-Martin, C., Downregulation of the calcium current in human right atrial myocytes from patients in sinus rhythm but with a high risk of atrial fibrillation (2008) Eur Heart J., 29 (9), pp. 1190-1197;Abramochkin, D.V., Haertdinov, N.N., Porokhnya, M.V., Zefirov, A.L., Sitdikova, G.F., Carbon monoxide affects electrical and contractile activity of rat myocardium (2011) J Biomed Sci., 18 (1), p. 40;Courtemanche, M., Ramirez, R., Nattel, S., Ionic targets for drug therapy and atrial fibrillation-induced electrical remodeling: Insights from a mathematical model (1999) Cardiovasc Res., 42 (2), pp. 477-489;Kneller, J., Zou, R., Vigmond, E.J., Wang, Z., Leon, J., Nattel, S., Cholinergic atrial fibrillation in a computer model of a two-dimensional sheet of canine atrial cells with realistic ionic properties (2002) Circ Res., 90 (9), pp. E73-E87;Ugarte, J.P., Tobón, C., Orozco-Duque, A., Andrade-Caicedo, H., Generation of fibrillatory dynamics in cardiac tissue: Fractional diffusion as arrhythmogenic mechanism modelling tool (2017) Applied Mathematical Sciences, 11 (13), pp. 637-650;Miller, K.A., Siscovick, D.S., Sheppard, L., Shepherd, K., Sullivan, J.H., Anderson, G.L., Long-term exposure to air pollution and incidence of cardiovascular events in women (2007) N Engl J Med., 356 (5), pp. 447-458;Brook, R.D., Franklin, B., Cascio, W., Hong, Y., Howard, G., Lipsett, M., Air pollution and cardiovascular disease: A statement for healthcare professionals from the expert panel on population and prevention science of the American Heart Association (2004) Circulation, 109 (21), pp. 2655-2671;Finkelstein, M., Pollution-related mortality and educational level (2002) JAMA, 288 (7), p. 830;Pope, C.A., Burnett, R.T., Thun, M.J., Calle, E.E., Krewski, D., Ito, K., Lung cancer, cardiopulmonary mortality, and longterm exposure to fine particulate air pollution (2002) JAMA, 287 (9), pp. 1132-1141;(2014) UNEP Year Book 2014 Emerging Issues Update. Air Pollution: World's Worst Environmental Health Risk, , UNEP Nairobi: United Nations Environment Programme, Environment for Development;Link, M.S., Luttmann-Gibson, H., Schwartz, J., Mittleman, M.A., Wessler, B., Gold, D.R., Acute exposure to air pollution triggers atrial fibrillation (2013) J Am Coll Cardiol, 62 (9), pp. 816-825 |
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IEEE Computer Society |
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Ciencias Básicas |
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Facultad de Ciencias Básicas |
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Scopus |
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Universidad de Medellín |
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Repositorio Institucional Universidad de Medellin |
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repositorio@udem.edu.co |
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1814159154083790848 |
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2018-10-31T13:44:24Z2018-10-31T13:44:24Z201723258861http://hdl.handle.net/11407/491410.22489/CinC.2017.123-037Exposure to air pollutants like lead (Pb++) and carbon monoxide (CO), promotes the occurrence of cardiovascular diseases. Experimental studies have shown that Pb++ and CO block the L-type calcium channels, decreasing the calcium current (ICaL) and the action potential duration (APD), favoring the initiation of atrial arrhythmias. Our goal is to study the effects of Pb++ and CO at different concentrations, on ICaL and action potential using computational simulation. For this, we developed mathematical models of the air pollutants effects on the atrial L-type calcium channel and they were incorporated in a mathematical model of human atrial cell and in a 2D model of atrial tissue. Our results suggest that the Pb++ and CO block the ICaL current in a fraction that increases as the concentration increases, generating an APD shortening. The combined effect of both air pollutants generated an APD shortening and a stable rotor, which is considered as a pro-arrhythmic effect. These results are consistent with experimental studies. In silico studies may contribute to a better understanding of the mechanisms by which air pollutants have unhealthy effects on cardiac system. © 2017 IEEE Computer Society. All rights reserved.engIEEE Computer SocietyCiencias BásicasFacultad de Ciencias Básicashttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85045124430&doi=10.22489%2fCinC.2017.123-037&partnerID=40&md5=fe262767368ee1e80a222bc4e723bae54414Computing in CardiologyThe cost of air pollution (2014) Health Impacts of Road Transport, pp. 1-80. , OECD OECD Publishing;National ambient air quality standards (NAAQS) | air and radiation | US EPA (2012) US Environ Prot Agency, off Air Qual Plan Stand, (4), pp. 2014-2015;(2016) Lead Poisoning and Health [Internet], , http://www.who.int/mediacentre/factsheets/fs379/en, World Health Organization;Henry, C.R., Satran, D., Lindgren, B., Adkinson, C., Nicholson, C.I., Henry, T.D., Myocardial injury and long-term mortality following moderate to severe carbon monoxide poisoning (2006) Am Med Assoc., 295 (4), pp. 398-402;Bhatnagar, A., Cardiovascular pathophysiology of environmental pollutants (2004) Am J Physiol Heart Circ Physiol, 286 (2), pp. H479-H485;Prentice, R., Kopp, S., Cardiotoxicity of lead at various perfusate calcium concentrations: Functional and metabolic responses of the perfused rat heart (1985) Toxicol Appl Pharmacol, 81, pp. 491-501;Ansari, M.A., Maayah, Z.H., Bakheet, S.A., El-Kadi, A.O., Korashy, H., The role of aryl hydrocarbon receptor signaling pathway in cardiotoxicity of acute lead intoxication in vivo and in vitro rat model (2013) Toxicology, 306, pp. 40-49;Samoli, E., Touloumi, G., Schwartz, J., Anderson, H.R., Schindler, C., Forsberg, B., Short-term effects of carbon monoxide on mortality: An analysis within the APHEA project (2007) Environ Health Perspect, 115 (11), pp. 1578-1583;Dales, R., Ambient carbon monoxide May influence heart rate variability in subjects with coronary artery disease (2004) Occup Env Med., 46 (12), pp. 1217-1221;Simkhovich, B.Z., Kleinman, M.T., Kloner, R.A., Air pollution and cardiovascular injury. Epidemiology, toxicology, and mechanisms (2008) Journal of the American College of Cardiology, 52 (9), pp. 719-726;(2013) Integrated Science Assessment (ISA) for Lead, , U.S. EPA Final Report, Jul Washington;2013;Bernal, J., Lee, J., Cribbs, L.L., Perezreyes, E., (1997) Full Reversal of Pb++ Block of L-Type Ca++ Channels Requires Treatment With Heavy Metal Antidotes1, 282 (1), pp. 172-180;Dinanian, S., Boixel, C., Juin, C., Hulot, J.-S., Coulombe, A., Rücker-Martin, C., Downregulation of the calcium current in human right atrial myocytes from patients in sinus rhythm but with a high risk of atrial fibrillation (2008) Eur Heart J., 29 (9), pp. 1190-1197;Abramochkin, D.V., Haertdinov, N.N., Porokhnya, M.V., Zefirov, A.L., Sitdikova, G.F., Carbon monoxide affects electrical and contractile activity of rat myocardium (2011) J Biomed Sci., 18 (1), p. 40;Courtemanche, M., Ramirez, R., Nattel, S., Ionic targets for drug therapy and atrial fibrillation-induced electrical remodeling: Insights from a mathematical model (1999) Cardiovasc Res., 42 (2), pp. 477-489;Kneller, J., Zou, R., Vigmond, E.J., Wang, Z., Leon, J., Nattel, S., Cholinergic atrial fibrillation in a computer model of a two-dimensional sheet of canine atrial cells with realistic ionic properties (2002) Circ Res., 90 (9), pp. E73-E87;Ugarte, J.P., Tobón, C., Orozco-Duque, A., Andrade-Caicedo, H., Generation of fibrillatory dynamics in cardiac tissue: Fractional diffusion as arrhythmogenic mechanism modelling tool (2017) Applied Mathematical Sciences, 11 (13), pp. 637-650;Miller, K.A., Siscovick, D.S., Sheppard, L., Shepherd, K., Sullivan, J.H., Anderson, G.L., Long-term exposure to air pollution and incidence of cardiovascular events in women (2007) N Engl J Med., 356 (5), pp. 447-458;Brook, R.D., Franklin, B., Cascio, W., Hong, Y., Howard, G., Lipsett, M., Air pollution and cardiovascular disease: A statement for healthcare professionals from the expert panel on population and prevention science of the American Heart Association (2004) Circulation, 109 (21), pp. 2655-2671;Finkelstein, M., Pollution-related mortality and educational level (2002) JAMA, 288 (7), p. 830;Pope, C.A., Burnett, R.T., Thun, M.J., Calle, E.E., Krewski, D., Ito, K., Lung cancer, cardiopulmonary mortality, and longterm exposure to fine particulate air pollution (2002) JAMA, 287 (9), pp. 1132-1141;(2014) UNEP Year Book 2014 Emerging Issues Update. Air Pollution: World's Worst Environmental Health Risk, , UNEP Nairobi: United Nations Environment Programme, Environment for Development;Link, M.S., Luttmann-Gibson, H., Schwartz, J., Mittleman, M.A., Wessler, B., Gold, D.R., Acute exposure to air pollution triggers atrial fibrillation (2013) J Am Coll Cardiol, 62 (9), pp. 816-825ScopusAir pollutionCalciumCalcium compoundsCarbon monoxideCardiologyAction potential durationsAction potentialsAtrial arrhythmiaCalcium currentCardio-vascular diseaseCombined effectComputational simulationL-type calcium channelsLead compoundsLead and carbon monoxide effects on human atrial action potential. In silico studyConference Paperinfo:eu-repo/semantics/conferenceObjecthttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_c94fTobón, C., Universidad de Medellín;Pachajoa, D.C., Instituto Tecnológico Metropolitano;Ugarte, J.P., Universidad de San Buenaventura;Orozco-Duque, A., Instituto Tecnológico Metropolitano;Saiz, J., Universitat Politècnica de ValènciaTobón C.Pachajoa D.C.Ugarte J.P.Orozco-Duque A.Saiz J.http://purl.org/coar/access_right/c_16ec11407/4914oai:repository.udem.edu.co:11407/49142020-05-27 16:36:14.698Repositorio Institucional Universidad de Medellinrepositorio@udem.edu.co |