Reaction mechanism of nucleoside 2’-deoxyribosyltransferases: free-energy landscape supports an oxocarbenium ion as the reaction intermediate

Insight into the catalytic mechanism of Lactobacillus leichmannii nucleoside 2′-deoxyribosyltransferase (LlNDT) has been gained by calculating a quantum mechanics–molecular mechanics (QM/MM) free-energy landscape of the reaction within the enzyme active site. Our results support an oxocarbenium spec...

Full description

Autores:

Del Arco, Jon
Perona Requena, Almudena
González, Leticia
Fernández Lucas, Jesús
Gago, Federico
Sánchez-Murcia, Pedro Alejandro

Tipo de recurso:

http://purl.org/coar/resource_type/c_816b

Fecha de publicación:

2019

Institución:

Corporación Universidad de la Costa

Repositorio:

REDICUC - Repositorio CUC

Idioma:

spa

OAI Identifier:

oai:repositorio.cuc.edu.co:11323/5253

Acceso en línea:

https://hdl.handle.net/11323/5253
https://repositorio.cuc.edu.co/

Palabra clave:

Nucleoside 2’-deoxyribosyltransferases
Oxocarbenium ion
Reaction intermediate

Rights

openAccess

License

CC0 1.0 Universal