TRF1 as a major contributor for telomeres’ shortening in the context of obesity
Obesity is a prevalent multifactorial chronic disorder characterized by metabolic dysregulation. Sustained pro-oxidative mediators trigger harmful consequences that reflect at systemic level and contribute for the establishment of a premature senescent phenotype associated with macromolecular damage...
- Autores:
-
Grun Kich, Lucas
Nevton Da Rosa, Teixeira
Mengden Von, Lúcia
De Bastiani, Marco Antônio
Parisi Migliorini, Mariana
Calixto Bortolin, Rafael
Lavandoski, Patrícia
Pierdona, Vinícius
Alves Biscaino, Letícia
Moreira Fonseca, José Cláudio
Mottin Corá, Cláudio
Jones, Marcus Herbert
Klamt, Fábio
Vontobel Padoin, Alexandre
Guma Costa R.Rodrigues, Fátima
Barbé Tuana, Florência María
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2018
- Institución:
- Corporación Universidad de la Costa
- Repositorio:
- REDICUC - Repositorio CUC
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.cuc.edu.co:11323/932
- Acceso en línea:
- http://hdl.handle.net/11323/932
https://repositorio.cuc.edu.co/
- Palabra clave:
- Aging
Obesity
Oxidative stress
Shelterin complex
Telomere length
TRF1
- Rights
- openAccess
- License
- Atribución – No comercial – Compartir igual
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|
dc.title.eng.fl_str_mv |
TRF1 as a major contributor for telomeres’ shortening in the context of obesity |
title |
TRF1 as a major contributor for telomeres’ shortening in the context of obesity |
spellingShingle |
TRF1 as a major contributor for telomeres’ shortening in the context of obesity Aging Obesity Oxidative stress Shelterin complex Telomere length TRF1 |
title_short |
TRF1 as a major contributor for telomeres’ shortening in the context of obesity |
title_full |
TRF1 as a major contributor for telomeres’ shortening in the context of obesity |
title_fullStr |
TRF1 as a major contributor for telomeres’ shortening in the context of obesity |
title_full_unstemmed |
TRF1 as a major contributor for telomeres’ shortening in the context of obesity |
title_sort |
TRF1 as a major contributor for telomeres’ shortening in the context of obesity |
dc.creator.fl_str_mv |
Grun Kich, Lucas Nevton Da Rosa, Teixeira Mengden Von, Lúcia De Bastiani, Marco Antônio Parisi Migliorini, Mariana Calixto Bortolin, Rafael Lavandoski, Patrícia Pierdona, Vinícius Alves Biscaino, Letícia Moreira Fonseca, José Cláudio Mottin Corá, Cláudio Jones, Marcus Herbert Klamt, Fábio Vontobel Padoin, Alexandre Guma Costa R.Rodrigues, Fátima Barbé Tuana, Florência María |
dc.contributor.author.spa.fl_str_mv |
Grun Kich, Lucas Nevton Da Rosa, Teixeira Mengden Von, Lúcia De Bastiani, Marco Antônio Parisi Migliorini, Mariana Calixto Bortolin, Rafael Lavandoski, Patrícia Pierdona, Vinícius Alves Biscaino, Letícia Moreira Fonseca, José Cláudio Mottin Corá, Cláudio Jones, Marcus Herbert Klamt, Fábio Vontobel Padoin, Alexandre Guma Costa R.Rodrigues, Fátima Barbé Tuana, Florência María |
dc.subject.eng.fl_str_mv |
Aging Obesity Oxidative stress Shelterin complex Telomere length TRF1 |
topic |
Aging Obesity Oxidative stress Shelterin complex Telomere length TRF1 |
description |
Obesity is a prevalent multifactorial chronic disorder characterized by metabolic dysregulation. Sustained pro-oxidative mediators trigger harmful consequences that reflect at systemic level and contribute for the establishment of a premature senescent phenotype associated with macromolecular damage (DNA, protein, and lipids). Telomeres are structures that protect chromosome ends and are associated with a six-protein complex called the shelterin complex and subject to regulation. Under pro-oxidant conditions, telomere attrition and the altered expression of the shelterin proteins are central for the establishment of many pathophysiological conditions such as obesity. Thus, considering that individuals with obesity display a systemic oxidative stress profile that may compromise the telomeres length or its regulation, the aim of this study was to investigate telomere homeostasis in patients with obesity and explore broad/systemic associations with the expression of shelterin genes and the plasma redox state. We performed a cross-sectional study in 39 patients with obesity and 27 eutrophic subjects. Telomere length (T/S ratio) and gene expression of shelterin components were performed in peripheral blood mononuclear cells by qPCR. |
publishDate |
2018 |
dc.date.accessioned.none.fl_str_mv |
2018-11-14T00:44:08Z |
dc.date.available.none.fl_str_mv |
2018-11-14T00:44:08Z |
dc.date.issued.none.fl_str_mv |
2018-09-24 |
dc.type.spa.fl_str_mv |
Artículo de revista |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.content.spa.fl_str_mv |
Text |
dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.redcol.spa.fl_str_mv |
http://purl.org/redcol/resource_type/ART |
dc.type.version.spa.fl_str_mv |
info:eu-repo/semantics/acceptedVersion |
format |
http://purl.org/coar/resource_type/c_6501 |
status_str |
acceptedVersion |
dc.identifier.issn.spa.fl_str_mv |
08915849 |
dc.identifier.uri.spa.fl_str_mv |
http://hdl.handle.net/11323/932 |
dc.identifier.doi.spa.fl_str_mv |
DOI: 10.1016/j.freeradbiomed.2018.09.039 |
dc.identifier.instname.spa.fl_str_mv |
Corporación Universidad de la Costa |
dc.identifier.reponame.spa.fl_str_mv |
REDICUC - Repositorio CUC |
dc.identifier.repourl.spa.fl_str_mv |
https://repositorio.cuc.edu.co/ |
identifier_str_mv |
08915849 DOI: 10.1016/j.freeradbiomed.2018.09.039 Corporación Universidad de la Costa REDICUC - Repositorio CUC |
url |
http://hdl.handle.net/11323/932 https://repositorio.cuc.edu.co/ |
dc.language.iso.none.fl_str_mv |
eng |
language |
eng |
dc.rights.spa.fl_str_mv |
Atribución – No comercial – Compartir igual |
dc.rights.accessrights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
dc.rights.coar.spa.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
rights_invalid_str_mv |
Atribución – No comercial – Compartir igual http://purl.org/coar/access_right/c_abf2 |
eu_rights_str_mv |
openAccess |
dc.publisher.spa.fl_str_mv |
Free Radical Biology And Medicine |
institution |
Corporación Universidad de la Costa |
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spelling |
Grun Kich, LucasNevton Da Rosa, TeixeiraMengden Von, LúciaDe Bastiani, Marco AntônioParisi Migliorini, MarianaCalixto Bortolin, RafaelLavandoski, PatríciaPierdona, ViníciusAlves Biscaino, LetíciaMoreira Fonseca, José CláudioMottin Corá, CláudioJones, Marcus HerbertKlamt, FábioVontobel Padoin, AlexandreGuma Costa R.Rodrigues, FátimaBarbé Tuana, Florência María2018-11-14T00:44:08Z2018-11-14T00:44:08Z2018-09-2408915849http://hdl.handle.net/11323/932DOI: 10.1016/j.freeradbiomed.2018.09.039Corporación Universidad de la CostaREDICUC - Repositorio CUChttps://repositorio.cuc.edu.co/Obesity is a prevalent multifactorial chronic disorder characterized by metabolic dysregulation. Sustained pro-oxidative mediators trigger harmful consequences that reflect at systemic level and contribute for the establishment of a premature senescent phenotype associated with macromolecular damage (DNA, protein, and lipids). Telomeres are structures that protect chromosome ends and are associated with a six-protein complex called the shelterin complex and subject to regulation. Under pro-oxidant conditions, telomere attrition and the altered expression of the shelterin proteins are central for the establishment of many pathophysiological conditions such as obesity. Thus, considering that individuals with obesity display a systemic oxidative stress profile that may compromise the telomeres length or its regulation, the aim of this study was to investigate telomere homeostasis in patients with obesity and explore broad/systemic associations with the expression of shelterin genes and the plasma redox state. We performed a cross-sectional study in 39 patients with obesity and 27 eutrophic subjects. Telomere length (T/S ratio) and gene expression of shelterin components were performed in peripheral blood mononuclear cells by qPCR.Grun Kich, Lucas-6a7dd59a-663d-4b52-9bda-b5c869fb7b64-0Nevton Da Rosa, Teixeira-fe0b8365-1afa-41a7-868d-368bb7a21b31-0Mengden Von, Lúcia-035ded7e-3335-4f7e-9201-93f305081c1a-0De Bastiani, Marco Antônio-06e45f6d-7cad-4b84-a5bb-4086c776b7f1-0Parisi Migliorini, Mariana-6bcd95c7-4ea9-40e1-bd65-71e6860b058a-0Calixto Bortolin, Rafael-0000-0003-4780-8499-600Lavandoski, Patrícia-d2d8b8e9-1ac2-43d7-a85c-7ef5e87c3941-0Pierdona, Vinícius-7d133ca0-a97f-4bf7-ae16-2ba18afb8c54-0Alves Biscaino, Letícia-0eb147fc-c9f8-4f3d-bd2c-d13e93db9f9c-0Moreira Fonseca, José Cláudio-4373df94-e345-42b4-861c-55953fd27b36-0Mottin Corá, Cláudio-4e7b7f71-dcf0-4b66-ba62-096aa76e8acb-0Jones, Marcus Herbert-2d3b247b-8515-4a74-97e6-33daa219d442-0Klamt, Fábio-6c9e5534-99d4-441c-a2c0-e4bbca7ce41e-0Vontobel Padoin, Alexandre-56927fc4-3d87-473a-988a-e19de80fd741-0Guma Costa R.Rodrigues, Fátima-8d422b94-54d7-4ffd-9986-eb749398d85c-0Barbé Tuana, Florência María-8bb037a3-e2e4-4e07-9137-654a385143af-0engFree Radical Biology And MedicineAtribución – No comercial – Compartir igualinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2AgingObesityOxidative stressShelterin complexTelomere lengthTRF1TRF1 as a major contributor for telomeres’ shortening in the context of obesityArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/acceptedVersionPublicationORIGINALTRF1 As A Major Contributor For Telomeres’.pdfTRF1 As A Major Contributor For Telomeres’.pdfapplication/pdf268620https://repositorio.cuc.edu.co/bitstreams/6e288957-2eeb-4cbd-bcc9-4f5810ff5925/download3cc2e0af2fa7cb2b48dfa245b65ab651MD51LICENSElicense.txtlicense.txttext/plain; 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