TRF1 as a major contributor for telomeres’ shortening in the context of obesity

Obesity is a prevalent multifactorial chronic disorder characterized by metabolic dysregulation. Sustained pro-oxidative mediators trigger harmful consequences that reflect at systemic level and contribute for the establishment of a premature senescent phenotype associated with macromolecular damage...

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Autores:: Grun Kich, Lucas
Nevton Da Rosa, Teixeira
Mengden Von, Lúcia
De Bastiani, Marco Antônio
Parisi Migliorini, Mariana
Calixto Bortolin, Rafael
Lavandoski, Patrícia
Pierdona, Vinícius
Alves Biscaino, Letícia
Moreira Fonseca, José Cláudio
Mottin Corá, Cláudio
Jones, Marcus Herbert
Klamt, Fábio
Vontobel Padoin, Alexandre
Guma Costa R.Rodrigues, Fátima
Barbé Tuana, Florência María

Tipo de recurso:: Article of journal

Fecha de publicación:: 2018

Institución:: Corporación Universidad de la Costa

Repositorio:: REDICUC - Repositorio CUC

Idioma:: eng

Description
Summary:	Obesity is a prevalent multifactorial chronic disorder characterized by metabolic dysregulation. Sustained pro-oxidative mediators trigger harmful consequences that reflect at systemic level and contribute for the establishment of a premature senescent phenotype associated with macromolecular damage (DNA, protein, and lipids). Telomeres are structures that protect chromosome ends and are associated with a six-protein complex called the shelterin complex and subject to regulation. Under pro-oxidant conditions, telomere attrition and the altered expression of the shelterin proteins are central for the establishment of many pathophysiological conditions such as obesity. Thus, considering that individuals with obesity display a systemic oxidative stress profile that may compromise the telomeres length or its regulation, the aim of this study was to investigate telomere homeostasis in patients with obesity and explore broad/systemic associations with the expression of shelterin genes and the plasma redox state. We performed a cross-sectional study in 39 patients with obesity and 27 eutrophic subjects. Telomere length (T/S ratio) and gene expression of shelterin components were performed in peripheral blood mononuclear cells by qPCR.

TRF1 as a major contributor for telomeres’ shortening in the context of obesity

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