Memory recovery through gene therapy with a single chain antibody fragment selective for Aβ oligomers in a model of Alzheimer’s disease in rats

Strong evidence supports the hypothesis that synapse damage and memory impairment in early Alzheimer disease (AD) might be due to synaptic failure caused by amyloid beta oligomers (AβOs). We demonstrated the preclinical efficacy of a single-chain variable-fragment (scFv) antibody NUsc1 that selectiv...

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Autores:

Colettis, Natalia
Oberholzer, Maria Victoria
Cercato, Magali
Habif, Martin
Selles, Maria Clara
Salas, Daniela
Sebollela, Adriano
Klein, William-L.
Epstein, Alberto
Salvetti, Anna
Ferreira, Sergio-T.
Jerusalinsky, Diana

Tipo de recurso:

Article of journal

Fecha de publicación:

2023

Institución:

Corporación Universidad de la Costa

Repositorio:

REDICUC - Repositorio CUC

Idioma:

eng

OAI Identifier:

oai:repositorio.cuc.edu.co:11323/10179

Acceso en línea:

https://hdl.handle.net/11323/10179
https://repositorio.cuc.edu.co/

Palabra clave:

LTM
Alzheimer’s disease
Gene therapy
ScFv
Single chain antibody fragment
Aβ oligomer
Memoria de larga duración MLD
Enfermedad de Alzheimer
Terapia génica
Fragmento de anticuerpo de cadena simple
Oligómeros Aβ

Rights

openAccess

License

Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)