Retinoic acid downregulates thiol antioxidant defences and homologous recombination while promotes A549 cells sensitization to cisplatin

Recent studies have investigated the use of retinoic acid (RA) molecule in combined chemotherapies to cancer cells as an attempt to increase treatment efficiency and circumvent cell resistance. Positive results were obtained in clinical trials from lung cancer patients treated with RA and cisplatin....

Full description

Autores:

Gasparotto, Juciano
Figueiró, Fabrício
de Fraga Dias, Amanda
Rostirolla, Diana Carolina
Somensi, Nauana
Taisda Rosa, Helen
Kich Grun, Lucas
Barbé Tuana, Florencia María

Tipo de recurso:

http://purl.org/coar/resource_type/c_816b

Fecha de publicación:

2019

Institución:

Corporación Universidad de la Costa

Repositorio:

REDICUC - Repositorio CUC

Idioma:

eng

OAI Identifier:

oai:repositorio.cuc.edu.co:11323/5233

Acceso en línea:

http://hdl.handle.net/11323/5233
https://repositorio.cuc.edu.co/

Palabra clave:

Retinoic acid
Cisplatin
A549 cells
NRF2
Antioxidants systems
Homologous recombination

Rights

openAccess

License

CC0 1.0 Universal