Structure‐guided tuning of a selectivity switch towards ribonucleosides in Trypanosoma brucei purine nucleoside 2' deoxyribosyltransferase

The use of nucleoside 2’‐deoxyribosyl‐transferases (NDTs) as biocatalysts for the industrial synthesis of nucleoside analogues is often hindered by their strict preference for 2’‐deoxyribonucleosides. We now show that a highly versatile purine nucleoside 2’‐deoxyribosyltransferase from Trypanosoma b...