Molecular basis of Ndt-mediated activation of nucleoside-based prodrugs and application in suicide gene therapy

Herein we report the first proof for the application of type II 2′-deoxyribosyltransferase from Lactobacillus delbrueckii (LdNDT) in suicide gene therapy for cancer treatment. To this end, we first confirm the hydrolytic ability of LdNDT over the nucleoside-based prodrugs 2′-deoxy-5-fluorouridine (d...

Full description

Autores:

Acosta, Javier
Pérez, Elena
Sánchez-Murcia, Pedro Alejandro
Fillat, Cristina
Fernández-Lucas, Jesús
Rosas, Ennis

Tipo de recurso:

Article of journal

Fecha de publicación:

2021

Institución:

Corporación Universidad de la Costa

Repositorio:

REDICUC - Repositorio CUC

Idioma:

eng

OAI Identifier:

oai:repositorio.cuc.edu.co:11323/7937

Acceso en línea:

https://hdl.handle.net/11323/7937
https://doi.org/10.3390/biom11010120
https://repositorio.cuc.edu.co/

Palabra clave:

Chemotherapy
Suicide gene therapy
Nucleoside analogues
2′-deoxyribosyltransferase
Structural bioinformatics
Molecular dynamics

Rights

openAccess

License

CC0 1.0 Universal