Synthesis and in vivo proof of concept of a BODIPY-based fluorescent probe as a tracer for biodistribution studies of a new anti-Chagas agent
The potential use of amide-containing thiazoles, especially (2E,2Z)-3-allyl-4-[((E)-4-cinnamylpiperazin-1-yl)carbonyl]-2-[2-((E)-3-(furan-2-yl)propenylidene)hydrazono]-2,3-dihydrothiazole (1), as drugs for the treatment of Chagas disease has been recently described. The therapeutic application of 1...
- Autores:
-
Rodríguez, Gonzalo
Nargoli, Javier
López, Andrés
Moyna, Guillermo
Álvarez, Guzmán
Fernández, Marcelo
Osorio Martinez, Carlos Alberto
González, Mercedes Florencia
Cerecetto, Hugo Eduardo
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2017
- Institución:
- Corporación Universidad de la Costa
- Repositorio:
- REDICUC - Repositorio CUC
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.cuc.edu.co:11323/1935
- Acceso en línea:
- http://hdl.handle.net/11323/1935
https://repositorio.cuc.edu.co/
- Palabra clave:
- Biodistributions
Chagas disease
Fluorescent probes
Fluorescent tracers
In-vitro
Pre-clinical
Proof of concept
Therapeutic Application
- Rights
- openAccess
- License
- Atribución – No comercial – Compartir igual
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oai:repositorio.cuc.edu.co:11323/1935 |
network_acronym_str |
RCUC2 |
network_name_str |
REDICUC - Repositorio CUC |
repository_id_str |
|
dc.title.eng.fl_str_mv |
Synthesis and in vivo proof of concept of a BODIPY-based fluorescent probe as a tracer for biodistribution studies of a new anti-Chagas agent |
title |
Synthesis and in vivo proof of concept of a BODIPY-based fluorescent probe as a tracer for biodistribution studies of a new anti-Chagas agent |
spellingShingle |
Synthesis and in vivo proof of concept of a BODIPY-based fluorescent probe as a tracer for biodistribution studies of a new anti-Chagas agent Biodistributions Chagas disease Fluorescent probes Fluorescent tracers In-vitro Pre-clinical Proof of concept Therapeutic Application |
title_short |
Synthesis and in vivo proof of concept of a BODIPY-based fluorescent probe as a tracer for biodistribution studies of a new anti-Chagas agent |
title_full |
Synthesis and in vivo proof of concept of a BODIPY-based fluorescent probe as a tracer for biodistribution studies of a new anti-Chagas agent |
title_fullStr |
Synthesis and in vivo proof of concept of a BODIPY-based fluorescent probe as a tracer for biodistribution studies of a new anti-Chagas agent |
title_full_unstemmed |
Synthesis and in vivo proof of concept of a BODIPY-based fluorescent probe as a tracer for biodistribution studies of a new anti-Chagas agent |
title_sort |
Synthesis and in vivo proof of concept of a BODIPY-based fluorescent probe as a tracer for biodistribution studies of a new anti-Chagas agent |
dc.creator.fl_str_mv |
Rodríguez, Gonzalo Nargoli, Javier López, Andrés Moyna, Guillermo Álvarez, Guzmán Fernández, Marcelo Osorio Martinez, Carlos Alberto González, Mercedes Florencia Cerecetto, Hugo Eduardo |
dc.contributor.author.spa.fl_str_mv |
Rodríguez, Gonzalo Nargoli, Javier López, Andrés Moyna, Guillermo Álvarez, Guzmán Fernández, Marcelo Osorio Martinez, Carlos Alberto González, Mercedes Florencia Cerecetto, Hugo Eduardo |
dc.subject.eng.fl_str_mv |
Biodistributions Chagas disease Fluorescent probes Fluorescent tracers In-vitro Pre-clinical Proof of concept Therapeutic Application |
topic |
Biodistributions Chagas disease Fluorescent probes Fluorescent tracers In-vitro Pre-clinical Proof of concept Therapeutic Application |
description |
The potential use of amide-containing thiazoles, especially (2E,2Z)-3-allyl-4-[((E)-4-cinnamylpiperazin-1-yl)carbonyl]-2-[2-((E)-3-(furan-2-yl)propenylidene)hydrazono]-2,3-dihydrothiazole (1), as drugs for the treatment of Chagas disease has been recently described. The therapeutic application of 1 requires further pre-clinical studies, including in vivo biodistribution. In this sense, a BODIPY-fluorophore based probe for this drug (1-BODIPY) was developed and investigated for its potential as an in vivo tracer. The fluorescent tracer was synthesized, physicochemically and in vitro biologically characterised, and its in vivo biodistribution evaluated. The in vitro studies demonstrated that the fluorescent probe could simulate the in vivo behaviour of compound 1. Furthermore, the in vivo proof of concept showed that the 1-BODIPY biodistribution involves organs that are associated with the parasitic disease. These findings allow us to establish future administration routes and regimens in the treatment of Chagas disease with 1. |
publishDate |
2017 |
dc.date.issued.none.fl_str_mv |
2017-01-07 |
dc.date.accessioned.none.fl_str_mv |
2018-11-27T14:27:14Z |
dc.date.available.none.fl_str_mv |
2018-11-27T14:27:14Z |
dc.type.spa.fl_str_mv |
Artículo de revista |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.content.spa.fl_str_mv |
Text |
dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.redcol.spa.fl_str_mv |
http://purl.org/redcol/resource_type/ART |
dc.type.version.spa.fl_str_mv |
info:eu-repo/semantics/acceptedVersion |
format |
http://purl.org/coar/resource_type/c_6501 |
status_str |
acceptedVersion |
dc.identifier.issn.spa.fl_str_mv |
20462069 |
dc.identifier.uri.spa.fl_str_mv |
http://hdl.handle.net/11323/1935 |
dc.identifier.instname.spa.fl_str_mv |
Corporación Universidad de la Costa |
dc.identifier.reponame.spa.fl_str_mv |
REDICUC - Repositorio CUC |
dc.identifier.repourl.spa.fl_str_mv |
https://repositorio.cuc.edu.co/ |
identifier_str_mv |
20462069 Corporación Universidad de la Costa REDICUC - Repositorio CUC |
url |
http://hdl.handle.net/11323/1935 https://repositorio.cuc.edu.co/ |
dc.language.iso.none.fl_str_mv |
eng |
language |
eng |
dc.rights.spa.fl_str_mv |
Atribución – No comercial – Compartir igual |
dc.rights.accessrights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
dc.rights.coar.spa.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
rights_invalid_str_mv |
Atribución – No comercial – Compartir igual http://purl.org/coar/access_right/c_abf2 |
eu_rights_str_mv |
openAccess |
dc.publisher.spa.fl_str_mv |
RSC Advances |
institution |
Corporación Universidad de la Costa |
bitstream.url.fl_str_mv |
https://repositorio.cuc.edu.co/bitstream/11323/1935/1/Synthesis%20and%20in%20vivo%20proof%20of%20concept%20of%20a%20BODIPY-based%20fluorescent.pdf https://repositorio.cuc.edu.co/bitstream/11323/1935/2/license.txt https://repositorio.cuc.edu.co/bitstream/11323/1935/4/Synthesis%20and%20in%20vivo%20proof%20of%20concept%20of%20a%20BODIPY-based%20fluorescent.pdf.jpg https://repositorio.cuc.edu.co/bitstream/11323/1935/5/Synthesis%20and%20in%20vivo%20proof%20of%20concept%20of%20a%20BODIPY-based%20fluorescent.pdf.txt |
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repository.name.fl_str_mv |
Repositorio Universidad de La Costa |
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Rodríguez, Gonzalo767c669df17ecbd3964133489a54b1bdNargoli, Javier650cba8e6f456a3848e51143506e9196López, Andrés9b947a9156433e9bc445a215b9e015c9Moyna, Guillermob52e13b0a5919136a2056af560c9d539Álvarez, Guzmán3c5c8f55e32b7caa75a42fcae7f932bfFernández, Marcelo1c3b472cebe07f9e4421e48f495b53c0Osorio Martinez, Carlos Alberto5d79f4db739eba9f0629ec9ded50947bGonzález, Mercedes Florencia114142e5c54a4b28d622ad0fd99c80c7Cerecetto, Hugo Eduardo8582082f0539422e123b158ff17aafff2018-11-27T14:27:14Z2018-11-27T14:27:14Z2017-01-0720462069http://hdl.handle.net/11323/1935Corporación Universidad de la CostaREDICUC - Repositorio CUChttps://repositorio.cuc.edu.co/The potential use of amide-containing thiazoles, especially (2E,2Z)-3-allyl-4-[((E)-4-cinnamylpiperazin-1-yl)carbonyl]-2-[2-((E)-3-(furan-2-yl)propenylidene)hydrazono]-2,3-dihydrothiazole (1), as drugs for the treatment of Chagas disease has been recently described. The therapeutic application of 1 requires further pre-clinical studies, including in vivo biodistribution. In this sense, a BODIPY-fluorophore based probe for this drug (1-BODIPY) was developed and investigated for its potential as an in vivo tracer. The fluorescent tracer was synthesized, physicochemically and in vitro biologically characterised, and its in vivo biodistribution evaluated. The in vitro studies demonstrated that the fluorescent probe could simulate the in vivo behaviour of compound 1. Furthermore, the in vivo proof of concept showed that the 1-BODIPY biodistribution involves organs that are associated with the parasitic disease. These findings allow us to establish future administration routes and regimens in the treatment of Chagas disease with 1.engRSC AdvancesAtribución – No comercial – Compartir igualinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2BiodistributionsChagas diseaseFluorescent probesFluorescent tracersIn-vitroPre-clinicalProof of conceptTherapeutic ApplicationSynthesis and in vivo proof of concept of a BODIPY-based fluorescent probe as a tracer for biodistribution studies of a new anti-Chagas agentArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/acceptedVersionORIGINALSynthesis and in vivo proof of concept of a BODIPY-based fluorescent.pdfSynthesis and in vivo proof of concept of a BODIPY-based fluorescent.pdfapplication/pdf3055229https://repositorio.cuc.edu.co/bitstream/11323/1935/1/Synthesis%20and%20in%20vivo%20proof%20of%20concept%20of%20a%20BODIPY-based%20fluorescent.pdfd7712b633b18e70d0d985996556d6093MD51open accessLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.cuc.edu.co/bitstream/11323/1935/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52open accessTHUMBNAILSynthesis and in vivo proof of concept of a BODIPY-based fluorescent.pdf.jpgSynthesis and in vivo proof of concept of a BODIPY-based fluorescent.pdf.jpgimage/jpeg68262https://repositorio.cuc.edu.co/bitstream/11323/1935/4/Synthesis%20and%20in%20vivo%20proof%20of%20concept%20of%20a%20BODIPY-based%20fluorescent.pdf.jpg95670c8c0367e5576595f713bf5c71f7MD54open accessTEXTSynthesis and in vivo proof of concept of a BODIPY-based fluorescent.pdf.txtSynthesis and in vivo proof of concept of a BODIPY-based fluorescent.pdf.txttext/plain30984https://repositorio.cuc.edu.co/bitstream/11323/1935/5/Synthesis%20and%20in%20vivo%20proof%20of%20concept%20of%20a%20BODIPY-based%20fluorescent.pdf.txt157fb45531a5f3f4e386ed9acc5bb956MD55open access11323/1935oai:repositorio.cuc.edu.co:11323/19352023-12-14 16:25:29.223open accessRepositorio Universidad de La Costabdigital@metabiblioteca.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 |