Enzymatic Synthesis Of Therapeutic Nucleosides Using A Highly Versatile Purine Nucleoside 2’-Deoxyribosyltransferase From Trypanosoma Brucei

The use of enzymes for the synthesis of nucleoside analogues offers several advantages over multistep chemical methods, including chemo-, regio- and stereoselectivity as well as milder reaction conditions. Herein, the production, characterization and utilization of a purine nucleoside 2’-deoxyribosy...

Full description

Autores:

Pérez, Elena
Sánchez Murcia, Pedro Alejandro
Jordaan, Justin
Blanco, María Dolores
Mancheño, José Miguel
Gago, Federico
Fernandez Lucas, Jesus

Tipo de recurso:

Article of journal

Fecha de publicación:

2018

Institución:

Corporación Universidad de la Costa

Repositorio:

REDICUC - Repositorio CUC

Idioma:

spa

OAI Identifier:

oai:repositorio.cuc.edu.co:11323/1015

Acceso en línea:

http://hdl.handle.net/11323/1015
https//doi.org/10.1002/cctc.201800775
https://repositorio.cuc.edu.co/

Palabra clave:

2‘-Deoxy-Ribosyltransferase
Biocatalysis
Enzyme Immobilization
Molecular Dynamics
Nucleoside Analogues

Rights

openAccess

License

Atribución – No comercial – Compartir igual