Hypoxanthine-Guanine Phosphoribosyltransferase/adenylate Kinase From Zobellia galactanivorans: A Bifunctional Catalyst for the Synthesis of Nucleoside-5′-Mono-, Di- and Triphosphates

In our search for novel biocatalysts for the synthesis of nucleic acid derivatives, we found a good candidate in a putative dual-domain hypoxanthine-guanine phosphoribosyltransferase (HGPRT)/adenylate kinase (AMPK) from Zobellia galactanivorans (ZgHGPRT/AMPK). In this respect, we report for the firs...

Full description

Autores:
Acosta, Javier
Del Arco, Jon
Del Pozo, Maria Luisa
Herrera, Beliña
Clemente-Suárez, Vicente Javier
Berenguer, José
Hidalgo, Aurelio
Fernández-Lucas, Jesús
Tipo de recurso:
Article of journal
Fecha de publicación:
2020
Institución:
Corporación Universidad de la Costa
Repositorio:
REDICUC - Repositorio CUC
Idioma:
eng
OAI Identifier:
oai:repositorio.cuc.edu.co:11323/6477
Acceso en línea:
https://hdl.handle.net/11323/6477
https://doi.org/10.3389/fbioe.2020.00677
https://repositorio.cuc.edu.co/
Palabra clave:
Enzymatic synthesis
Nucleotides
Phosphoribosyltransferase
Nucleoside-5cpsdummy′-monophosphate kinase
Dual domain protein
Rights
openAccess
License
CC0 1.0 Universal