BRCA-1 depletion impairs pro-inflammatory polarization and activation of RAW 264.7 macrophages in a NF-κB-dependent mechanism

BRCA-1 is a nuclear protein involved in DNA repair, transcriptional regulation, and cell cycle control. Its involvement in other cellular processes has been described. Here, we aimed to investigate the role of BRCA-1 in macrophages M(LPS), M(IL-4), and tumor cell-induced differentiation. We used siR...

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Autores:
da Silva Morrone, Maurilio
Somensi, Nauana
Franz, Lucas
de Miranda Ramos, Vitor
Gasparotto, Juciano
Taís da Rosa, Helen
Sartori, Marcelo
Figueiró, Fabrício
Gelain, Daniel
ZANOTTO-FILHO, ALFEU
Moreira, José Cláudio Fonseca
Tipo de recurso:
http://purl.org/coar/resource_type/c_816b
Fecha de publicación:
2019
Institución:
Corporación Universidad de la Costa
Repositorio:
REDICUC - Repositorio CUC
Idioma:
eng
OAI Identifier:
oai:repositorio.cuc.edu.co:11323/5657
Acceso en línea:
https://hdl.handle.net/11323/5657
https://repositorio.cuc.edu.co/
Palabra clave:
BRCA-1
Inflammation
M(LPS) and M(IL-4) polarization
Macrophage activation
Rights
openAccess
License
CC0 1.0 Universal