BRCA-1 depletion impairs pro-inflammatory polarization and activation of RAW 264.7 macrophages in a NF-κB-dependent mechanism
BRCA-1 is a nuclear protein involved in DNA repair, transcriptional regulation, and cell cycle control. Its involvement in other cellular processes has been described. Here, we aimed to investigate the role of BRCA-1 in macrophages M(LPS), M(IL-4), and tumor cell-induced differentiation. We used siR...
- Autores:
-
da Silva Morrone, Maurilio
Somensi, Nauana
Franz, Lucas
de Miranda Ramos, Vitor
Gasparotto, Juciano
Taís da Rosa, Helen
Sartori, Marcelo
Figueiró, Fabrício
Gelain, Daniel
ZANOTTO-FILHO, ALFEU
Moreira, José Cláudio Fonseca
- Tipo de recurso:
- http://purl.org/coar/resource_type/c_816b
- Fecha de publicación:
- 2019
- Institución:
- Corporación Universidad de la Costa
- Repositorio:
- REDICUC - Repositorio CUC
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.cuc.edu.co:11323/5657
- Acceso en línea:
- http://hdl.handle.net/11323/5657
https://repositorio.cuc.edu.co/
- Palabra clave:
- BRCA-1
Inflammation
M(LPS) and M(IL-4) polarization
Macrophage activation
- Rights
- openAccess
- License
- CC0 1.0 Universal