Anti-leishmanial evaluation of C2-aryl quinolines: Mechanistic insight on bioenergetics and sterol biosynthetic pathway of Leishmania braziliensis

A series of diverse simple C2-aryl quinolines was synthesized de novo via a straightforward synthesis based on the acid-catalyzed multicomponent imino Diels–Alder reactions. Seven selected quinolines were evaluated at different stages of Leishmania braziliensis parasite. Among them, the 6-ethyl-2-ph...

Full description

Autores:

Tipo de recurso:

Fecha de publicación:

2013

Institución:

Ministerio de Ciencia, Tecnología e Innovación

Repositorio:

Repositorio Minciencias

Idioma:

eng

OAI Identifier:

oai:repositorio.minciencias.gov.co:20.500.14143/34158

Acceso en línea:

http://repositorio.colciencias.gov.co/handle/11146/34158

Palabra clave:

Aceites vegetales
Biomasa
Chemotherapy
L. braziliensis
Parasite bioenergetics
Sterol biosynthetic pathway
C2-aryl substituted quinolines
Botánica
Aceites esenciales
Bioquímica vegetal
Química agrícola
Leishmaniosis
Medicina tropical

Rights

License

http://purl.org/coar/access_right/c_f1cf