A neurodegenerative disease landscape of rare mutations in Colombia due to founder effects

Background: The Colombian population, as well as those in other Latin American regions, arose from a recent tri-continental admixture among Native Americans, Spanish invaders, and enslaved Africans, all of whom passed through a population bottleneck due to widespread infectious diseases that left sm...

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Autores:

Acosta‑Uribe, Juliana
Aguillón, David
Cochran, J. Nicholas
Giraldo, Margarita
Madrigal, Lucía
Killingsworth, Bradley W.
Singhal, Rijul
Labib, Sarah
Alzate, Diana
Moreno, Sonia
García, Gloria P.
Saldarriaga, Amanda
Piedrahita, Francisco
Hincapié, Liliana
López, Hugo E
Perumal, Nithesh
Morelo, Leonilde
Vallejo, Dionis
Solano, Juan Marcos
Reiman, Eric M.
Surace, Ezequiel I.
Itzcovich, Tatiana
Allegri, Ricardo
Sánchez‑Valle, Raquel
Villegas‑Lanau, Andrés
White III, Charles L
Matallana, Diana
Myers, Richard M.
Browning, Sharon R.
Lopera, Francisco
Kosik, Kenneth S.

Tipo de recurso:

Article of investigation

Fecha de publicación:

2022

Institución:

Pontificia Universidad Javeriana

Repositorio:

Repositorio Universidad Javeriana

Idioma:

eng

OAI Identifier:

oai:repository.javeriana.edu.co:10554/59327

Acceso en línea:

https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-022-01035-9
http://hdl.handle.net/10554/59327
https://doi.org/10.1186/s13073-022-01035-9

Palabra clave:

Efecto fundador
Embotellamiento
Mezcla
Deriva genética
Selección
Demografía
neurodegeneración
Enfermedad De Alzheimer
Demencia Frontotemporal
Enfermedad de la neuronas motoras
Founder effect
Bottleneck
Admixture
Genetic drift
Selection
Demography
Neurodegeneration
Alzheimer’s disease
Frontotemporal dementia
Motor neuron disease

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