Unfolding Ubiquitin by force: water mediated H-bond destabilization

Using the “pull and wait” (PNW) simulation protocol at 300 K, we studied the unfolding by force of an ubiquitin molecule. PNW was implemented in the CHARMM program using an integration time step of 1 fs and a uniform dielectric constant of 1. The ubiquitin molecule, initially solvated, was put under...

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Autores:: Pabón, Germán; Departamento de Física Facultad de Ciencias Pontificia Universidad Javeriana
Amzel, Mario; Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine. Baltimore, USA.

Tipo de recurso:: Article of journal

Fecha de publicación:: 2012

Institución:: Pontificia Universidad Javeriana

Repositorio:: Repositorio Universidad Javeriana

Idioma:: eng