Early Islet Damage After Direct Exposure of Pig Islets to Blood:Has Humoral Immunity Been Underestimated?
Currently, islet transplantation as a cell therapeutic option for type 1 diabetes occurs via islet injection into the portal vein. Direct contact between islets and blood is a pathophysiological “provocation” that results in the instant blood-mediated inflammatory reaction (IBMIR) and is associated...
- Autores:
-
Van der Windt, Dirk J.
Trucco, Massimo
Echeverri Junca, Gabriel Jaime
Bottino, Rita
Cooper, David K. C.
Lakkis, Fadi G.
Ayares, David
Ekser, Burcin
Votyakova, Tatyana V.
He, Jing
Marigliano, Marco
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2012
- Institución:
- Universidad ICESI
- Repositorio:
- Repositorio ICESI
- Idioma:
- eng
- OAI Identifier:
- oai:repository.icesi.edu.co:10906/81202
- Acceso en línea:
- http://openurl.ingenta.com/content/xref?genre=article&issn=0963-6897&volume=21&issue=8&spage=1791
http://journals.sagepub.com/doi/pdf/10.3727/096368912X653011
http://hdl.handle.net/10906/81202
http://dx.doi.org/10.3727/096368912X653011
- Palabra clave:
- Anticuerpos
Inmunidad humoral
Ciencias socio biomédicas
Medical sciences
Xenotrasplantes
Trasplante de islotes
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by-nc-nd/4.0/
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Van der Windt, Dirk J.Trucco, MassimoEcheverri Junca, Gabriel JaimeBottino, RitaCooper, David K. C.Lakkis, Fadi G.Ayares, DavidEkser, BurcinVotyakova, Tatyana V.He, JingMarigliano, MarcoNew York de Lat: 43 00 00 N degrees minutes Lat: 43.0000 decimal degrees Long: 075 00 00 W degrees minutes Long: -75.0000 decimal degrees2017-03-30T22:41:56Z2017-03-30T22:41:56Z2012-08-010963-6897http://openurl.ingenta.com/content/xref?genre=article&issn=0963-6897&volume=21&issue=8&spage=1791http://journals.sagepub.com/doi/pdf/10.3727/096368912X653011http://hdl.handle.net/10906/81202http://dx.doi.org/10.3727/096368912X653011instname: Universidad Icesireponame: Biblioteca Digitalrepourl: https://repository.icesi.edu.co/Currently, islet transplantation as a cell therapeutic option for type 1 diabetes occurs via islet injection into the portal vein. Direct contact between islets and blood is a pathophysiological “provocation” that results in the instant blood-mediated inflammatory reaction (IBMIR) and is associated with early islet loss. However, the nature of the various insults on the islets in the blood stream remains mostly unknown. To gain insight into the mechanisms, we utilized a simplified in vitro model in which islets were exposed to blood in different clinically relevant but increasingly challenging, autologous, allogeneic, and xenogeneic combinations. Irrespective of the blood type and species compatibility, islets triggered blood clotting11 páginasDigitalapplication/pdfengCognizant Communication CorporationFacultad Ciencias de la SaludMedicinaDepartamento de Ciencias Básicas MédicasNew YorkCell Transplantation, Vol. 21, No. 8 - 2012,EL AUTOR, expresa que la obra objeto de la presente autorización es original y la elaboró sin quebrantar ni suplantar los derechos de autor de terceros, y de tal forma, la obra es de su exclusiva autoría y tiene la titularidad sobre éste. PARÁGRAFO: en caso de queja o acción por parte de un tercero referente a los derechos de autor sobre el artículo, folleto o libro en cuestión, EL AUTOR, asumirá la responsabilidad total, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos, la Universidad Icesi actúa como un tercero de buena fe. Esta autorización, permite a la Universidad Icesi, de forma indefinida, para que en los términos establecidos en la Ley 23 de 1982, la Ley 44 de 1993, leyes y jurisprudencia vigente al respecto, haga publicación de este con fines educativos. Toda persona que consulte ya sea la biblioteca o en medio electrónico podrá copiar apartes del texto citando siempre la fuentes, es decir el título del trabajo y el autor.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)http://purl.org/coar/access_right/c_abf2AnticuerposInmunidad humoralCiencias socio biomédicasMedical sciencesXenotrasplantesTrasplante de islotesEarly Islet Damage After Direct Exposure of Pig Islets to Blood:Has Humoral Immunity Been Underestimated?info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_2df8fbb1Artículoinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/version/c_970fb48d4fbd8a85Comunidad Universidad Icesi – Investigadores2117911802TEXTecheverri_early_iIslet_2012.pdf.txtecheverri_early_iIslet_2012.pdf.txttext/plain49015http://repository.icesi.edu.co/biblioteca_digital/bitstream/10906/81202/2/echeverri_early_iIslet_2012.pdf.txt3d11c9a756629f9e50c2081cfeef7b7fMD52ORIGINALecheverri_early_iIslet_2012.pdfecheverri_early_iIslet_2012.pdfapplication/pdf544692http://repository.icesi.edu.co/biblioteca_digital/bitstream/10906/81202/1/echeverri_early_iIslet_2012.pdf156606f6d717b0517da8400625bc6e66MD5110906/81202oai:repository.icesi.edu.co:10906/812022017-10-18 02:31:55.936Biblioteca Digital - Universidad icesicdcriollo@icesi.edu.co |
| dc.title.spa.fl_str_mv |
Early Islet Damage After Direct Exposure of Pig Islets to Blood:Has Humoral Immunity Been Underestimated? |
| title |
Early Islet Damage After Direct Exposure of Pig Islets to Blood:Has Humoral Immunity Been Underestimated? |
| spellingShingle |
Early Islet Damage After Direct Exposure of Pig Islets to Blood:Has Humoral Immunity Been Underestimated? Anticuerpos Inmunidad humoral Ciencias socio biomédicas Medical sciences Xenotrasplantes Trasplante de islotes |
| title_short |
Early Islet Damage After Direct Exposure of Pig Islets to Blood:Has Humoral Immunity Been Underestimated? |
| title_full |
Early Islet Damage After Direct Exposure of Pig Islets to Blood:Has Humoral Immunity Been Underestimated? |
| title_fullStr |
Early Islet Damage After Direct Exposure of Pig Islets to Blood:Has Humoral Immunity Been Underestimated? |
| title_full_unstemmed |
Early Islet Damage After Direct Exposure of Pig Islets to Blood:Has Humoral Immunity Been Underestimated? |
| title_sort |
Early Islet Damage After Direct Exposure of Pig Islets to Blood:Has Humoral Immunity Been Underestimated? |
| dc.creator.fl_str_mv |
Van der Windt, Dirk J. Trucco, Massimo Echeverri Junca, Gabriel Jaime Bottino, Rita Cooper, David K. C. Lakkis, Fadi G. Ayares, David Ekser, Burcin Votyakova, Tatyana V. He, Jing Marigliano, Marco |
| dc.contributor.author.spa.fl_str_mv |
Van der Windt, Dirk J. Trucco, Massimo Echeverri Junca, Gabriel Jaime Bottino, Rita Cooper, David K. C. Lakkis, Fadi G. Ayares, David Ekser, Burcin Votyakova, Tatyana V. He, Jing Marigliano, Marco |
| dc.subject.spa.fl_str_mv |
Anticuerpos Inmunidad humoral |
| topic |
Anticuerpos Inmunidad humoral Ciencias socio biomédicas Medical sciences Xenotrasplantes Trasplante de islotes |
| dc.subject.none.fl_str_mv |
Ciencias socio biomédicas Medical sciences Xenotrasplantes Trasplante de islotes |
| description |
Currently, islet transplantation as a cell therapeutic option for type 1 diabetes occurs via islet injection into the portal vein. Direct contact between islets and blood is a pathophysiological “provocation” that results in the instant blood-mediated inflammatory reaction (IBMIR) and is associated with early islet loss. However, the nature of the various insults on the islets in the blood stream remains mostly unknown. To gain insight into the mechanisms, we utilized a simplified in vitro model in which islets were exposed to blood in different clinically relevant but increasingly challenging, autologous, allogeneic, and xenogeneic combinations. Irrespective of the blood type and species compatibility, islets triggered blood clotting |
| publishDate |
2012 |
| dc.date.issued.none.fl_str_mv |
2012-08-01 |
| dc.date.accessioned.none.fl_str_mv |
2017-03-30T22:41:56Z |
| dc.date.available.none.fl_str_mv |
2017-03-30T22:41:56Z |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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Artículo |
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info:eu-repo/semantics/publishedVersion |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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publishedVersion |
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0963-6897 |
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http://openurl.ingenta.com/content/xref?genre=article&issn=0963-6897&volume=21&issue=8&spage=1791 |
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http://journals.sagepub.com/doi/pdf/10.3727/096368912X653011 |
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http://hdl.handle.net/10906/81202 |
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http://dx.doi.org/10.3727/096368912X653011 |
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instname: Universidad Icesi |
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reponame: Biblioteca Digital |
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repourl: https://repository.icesi.edu.co/ |
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0963-6897 instname: Universidad Icesi reponame: Biblioteca Digital repourl: https://repository.icesi.edu.co/ |
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http://openurl.ingenta.com/content/xref?genre=article&issn=0963-6897&volume=21&issue=8&spage=1791 http://journals.sagepub.com/doi/pdf/10.3727/096368912X653011 http://hdl.handle.net/10906/81202 http://dx.doi.org/10.3727/096368912X653011 |
| dc.language.iso.eng.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartof.none.fl_str_mv |
Cell Transplantation, Vol. 21, No. 8 - 2012, |
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https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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info:eu-repo/semantics/openAccess |
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Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0) |
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openAccess |
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11 páginas |
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application/pdf |
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New York de Lat: 43 00 00 N degrees minutes Lat: 43.0000 decimal degrees Long: 075 00 00 W degrees minutes Long: -75.0000 decimal degrees |
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Cognizant Communication Corporation |
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Facultad Ciencias de la Salud |
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Medicina |
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Departamento de Ciencias Básicas Médicas |
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New York |
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Cognizant Communication Corporation |
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Universidad ICESI |
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