Early Islet Damage After Direct Exposure of Pig Islets to Blood:Has Humoral Immunity Been Underestimated?

Currently, islet transplantation as a cell therapeutic option for type 1 diabetes occurs via islet injection into the portal vein. Direct contact between islets and blood is a pathophysiological “provocation” that results in the instant blood-mediated inflammatory reaction (IBMIR) and is associated...

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Autores:
Van der Windt, Dirk J.
Trucco, Massimo
Echeverri Junca, Gabriel Jaime
Bottino, Rita
Cooper, David K. C.
Lakkis, Fadi G.
Ayares, David
Ekser, Burcin
Votyakova, Tatyana V.
He, Jing
Marigliano, Marco
Tipo de recurso:
Article of investigation
Fecha de publicación:
2012
Institución:
Universidad ICESI
Repositorio:
Repositorio ICESI
Idioma:
eng
OAI Identifier:
oai:repository.icesi.edu.co:10906/81202
Acceso en línea:
http://openurl.ingenta.com/content/xref?genre=article&issn=0963-6897&volume=21&issue=8&spage=1791
http://journals.sagepub.com/doi/pdf/10.3727/096368912X653011
http://hdl.handle.net/10906/81202
http://dx.doi.org/10.3727/096368912X653011
Palabra clave:
Anticuerpos
Inmunidad humoral
Ciencias socio biomédicas
Medical sciences
Xenotrasplantes
Trasplante de islotes
Rights
openAccess
License
https://creativecommons.org/licenses/by-nc-nd/4.0/