Amyloid-β precursor protein modulates the sorting of testican-1 and contributes to its accumulation in brain tissue and cerebrospinal fluid from patients with Alzheimer disease

The mechanisms leading to amyloid-β (Aβ) accumulation in sporadic Alzheimer disease (AD) are unknown but both increased production or impaired clearance likely contribute to aggregation. To understand the potential roles of the extracellular matrix proteoglycan Testican-1 in the pathophysiology of A...

Full description

Autores:

Puig, Berta
Hartmann, Ursula
Matschke, Jakob
Arlt, Sönke
Barrera Ocampo, Álvaro Andrés
Sepúlveda-Falla, Diego
Ferrer, Isidre Sidre

Tipo de recurso:

Article of investigation

Fecha de publicación:

2016

Institución:

Universidad ICESI

Repositorio:

Repositorio ICESI

Idioma:

eng

OAI Identifier:

oai:repository.icesi.edu.co:10906/81729

Acceso en línea:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-84991278442&doi=10.1093%2fjnen%2fnlw065&partnerID=40&md5=3f940172a1edc529e78bff5e902268d9
http://hdl.handle.net/10906/81729
https://doi.org/10.1093/jnen/nlw065

Palabra clave:

Enfermedad de Alzheimer
Endosomas tempranos
Biología
Métodos de investigación en bioquímica
Biology
Biochemistry research

Rights

License

https://creativecommons.org/licenses/by-nc-nd/4.0/