Critical role of HLA-DR?* binding peptides' peripheral flanking residues in fully-protective malaria vaccine development

A vaccine candidate component must fit perfectly into the antigen presenting HLA-DR?* molecule's groove (or canonical nonapeptide) peptide binding region (PBR) during antigen presentation to the T-cell receptor (TCR), conforming a specific and stable macromolecular complex and induce an appropr...

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Autores:

Tipo de recurso:

Fecha de publicación:

2017

Institución:

Universidad del Rosario

Repositorio:

Repositorio EdocUR - U. Rosario

Idioma:

eng

OAI Identifier:

oai:repository.urosario.edu.co:10336/23517

Acceso en línea:

https://doi.org/10.1016/j.bbrc.2017.05.123
https://repository.urosario.edu.co/handle/10336/23517

Palabra clave:

HLA DR antigen
Malaria vaccine
HLA DRB1 antigen
Malaria vaccine
Peptide
Animal experiment
Aotus
Article
Binding affinity
Hydrogen bond
Immunogenicity
Immunological memory
Nonhuman
Physical chemistry
Priority journal
Protein structure
Sequence analysis
Structure analysis
Animal
Aotidae
Binding site
Chemistry
Immunology
Synthesis
Animals
Aotidae
Binding Sites
HLA-DRB1 Chains
Malaria Vaccines
Peptides
Amino acid side-chain polarity
Immune protection-inducing peptide structure (IMPIPS)
MHCII-peptide-TCR complex
Peripheral flanking residues

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