Integrative analysis of global gene expression identifies opposite patterns of reactive astrogliosis in aged human prefrontal cortex

The prefrontal cortex (PFC) is one of the brain regions with more prominent changes in human aging. The molecular processes related to the cognitive decline and mood changes during aging are not completely understood. To improve our knowledge, we integrated transcriptomic data of four studies of hum...

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Autores:

Tipo de recurso:

Fecha de publicación:

2018

Institución:

Universidad del Rosario

Repositorio:

Repositorio EdocUR - U. Rosario

Idioma:

eng

OAI Identifier:

oai:repository.urosario.edu.co:10336/23603

Acceso en línea:

https://doi.org/10.3390/brainsci8120227
https://repository.urosario.edu.co/handle/10336/23603

Palabra clave:

4 aminobutyric acid
Alpha interferon
Beta interferon
Cadmium
Cell protein
Cyclic gmp
Ezrin
Glutamic acid
Interferon
Metallothionein i
Moesin
Oxytocin
Radixin
Sonic hedgehog protein
Transcription factor gli1
Transcriptional activator gli3
Transient receptor potential channel
Zinc finger protein gli2
Adult
Aged
Aging
Article
Astrocyte
Astrocytosis
Comparative study
Down regulation
Gene expression
Gene expression profiling
Genetic analysis
Human
Meta analysis
Molecular biology
Neuroprotection
Phenotypic variation
Prefrontal cortex
Transcriptomics
Upregulation
Meta-analysis of transcriptomic
Prefrontal cortex aging
Reactive astrogliosis
Synapsis aging

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