Evaluation of imputation-based association in and around the integrin-?-M (ITGAM) gene and replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE)

We recently identified a novel non-synonymous variant, rs1143679, at exon 3 of the ITGAM gene associated with systemic lupus erythematosus (SLE) susceptibility in European-Americans (EAs) and African-Americans. Using genome-wide association approach, three other studies also independently reported a...

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Autores:

Tipo de recurso:

Fecha de publicación:

2009

Institución:

Universidad del Rosario

Repositorio:

Repositorio EdocUR - U. Rosario

Idioma:

eng

OAI Identifier:

oai:repository.urosario.edu.co:10336/24221

Acceso en línea:

https://doi.org/10.1093/hmg/ddp007
https://repository.urosario.edu.co/handle/10336/24221

Palabra clave:

Alpha integrin
Alpha m integrin
Alpha x integrin
Gene product
Integrin
Protein trim2
Unclassified drug
African american
Article
Controlled study
European american
Exon
Female
Gene frequency
Gene replication
Gene structure
Genetic association
Genetic code
Genetic susceptibility
Genetic variability
Geographic distribution
Geographic origin
Haplotype
Human
Japan
Korea
Major clinical study
Male
Priority journal
Race difference
Systemic lupus erythematosus
Alleles
Antigens, cd11b
Asian continental ancestry group
Bayes theorem
Case-control studies
Colombia
Demography
European continental ancestry group
Female
Genetic predisposition to disease
Great britain
Haplotypes
Hispanic americans
Humans
Japan
Korea
Linkage disequilibrium
Male
Meta-analysis as topic
Mexico
Reproducibility of results
systemic
single nucleotide
Lupus erythematosus
Polymorphism

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