Decreased SMG7 expression associates with lupus-risk variants and elevated antinuclear antibody production

Objectives Following up the systemic lupus erythematosus (SLE) genome-wide association studies (GWAS) identification of NMNAT2 at rs2022013, we fine-mapped its 150a €...kb flanking regions containing NMNAT2 and SMG7 in a 15a €...292 case-control multi-ancestry population and tested functions of iden...

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Autores:

Tipo de recurso:

Fecha de publicación:

2016

Institución:

Universidad del Rosario

Repositorio:

Repositorio EdocUR - U. Rosario

Idioma:

eng

OAI Identifier:

oai:repository.urosario.edu.co:10336/22456

Acceso en línea:

https://doi.org/10.1136/annrheumdis-2015-208441
https://repository.urosario.edu.co/handle/10336/22456

Palabra clave:

Antinuclear antibody
Immunoglobulin g
Ribonucleoprotein antibody
Sm antibody
Small interfering rna
Antinuclear antibody
Carrier protein
Messenger rna
Nicotinamide nucleotide adenylyltransferase
Allele
Antibody production
Antibody titer
Article
Case control study
Cell culture
Controlled study
Correlational study
Embryo
Ethnic difference
Gene
Gene expression
Gene function
Gene linkage disequilibrium
Gene silencing
Genetic association
Genetic transcription
Genetic variability
Genotype
Human
Human cell
Luciferase assay
Major clinical study
Multicenter study (topic)
Nmnat2 gene
Peripheral blood mononuclear cell
Priority journal
Promoter region
Quantitative trait locus
Raji cell line
Real time polymerase chain reaction
Regulatory mechanism
Risk
Single nucleotide polymorphism
Smg7 gene
Systemic lupus erythematosus
American indian
Caucasian
Female
Genetic predisposition
Genetics
Genome-wide association study
Genotyping technique
Hek293 cell line
Hispanic
Immunology
Male
Metabolism
Mononuclear cell
Pedigree
Risk factor
Systemic lupus erythematosus
Alleles
American native continental ancestry group
Carrier proteins
European continental ancestry group
Female
Genetic predisposition to disease
Genome-wide association study
Genotyping techniques
Hek293 cells
Hispanic americans
Humans
Linkage disequilibrium
Male
Nicotinamide-nucleotide adenylyltransferase
Pedigree
Real-time polymerase chain reaction
Risk factors
Autoantibodies
Gene polymorphism
Systemic lupus erythematosus
systemic
antinuclear
human
human
messenger
mononuclear
Nmnat2 protein
Smg7 protein
Antibodies
Leukocytes
Lupus erythematosus
Rna

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