Temozolomide down-regulates P-glycoprotein in human blood-brain barrier cells by disrupting Wnt3 signaling

Low delivery of many anticancer drugs across the blood-brain barrier (BBB) is a limitation to the success of chemotherapy in glioblastoma. This is because of the high levels of ATP-binding cassette transporters like P-glycoprotein (Pgp/ABCB1), which effluxes drugs back to the bloodstream. Temozolomi...

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Autores:

Tipo de recurso:

Fecha de publicación:

2014

Institución:

Universidad del Rosario

Repositorio:

Repositorio EdocUR - U. Rosario

Idioma:

eng

OAI Identifier:

oai:repository.urosario.edu.co:10336/23644

Acceso en línea:

https://doi.org/10.1007/s00018-013-1397-y
https://repository.urosario.edu.co/handle/10336/23644

Palabra clave:

ABC transporter
Beta catenin
Beta tubulin
Caspase 3
Claudin 3
Claudin 5
Doxorubicin
Glycogen synthase kinase 3
Hoe 33342
Multidrug resistance protein
Multidrug resistance protein 1
Occludin
Protein ZO1
Rhodamine 123
Temozolomide
Antineoplastic activity
Article
Blood brain barrier
Cell count
Cell permeabilization
Cell proliferation
Concentration (parameters)
Controlled study
Cytotoxicity
Down regulation
Drug efficacy
Drug penetration
Gene
Genetic transcription
Glioblastoma
Human
Human cell
MDR1 gene
Protein expression
Protein function
Protein transport
Wnt signaling pathway
Antineoplastic Agents
Beta Catenin
Blood-Brain Barrier
Capillary Permeability
Dacarbazine
DNA Methylation
Gene Expression Regulation
Humans
P-Glycoprotein
Signal Transduction
Wnt3 Protein
Blood-brain barrier
Glioblastoma multiforme
P-glycoprotein
Temozolomide
Wnt3
Tumor
Genetic
Cell Line
Promoter Regions

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