Combined protein-and nucleic acid-level effects of rs1143679 (R77H), a lupus-predisposing variant within ITGAM

Integrin alpha M(ITGAM; CD11b) is a component of the macrophage-1 antigen complex, which mediates leukocyte adhesion, migration and phagocytosis as part of the immune system.We previously identified amissense polymorphism, rs1143679 (R77H), strongly associated with systemic lupus erythematosus (SLE)...

Full description

Autores:

Tipo de recurso:

Fecha de publicación:

2014

Institución:

Universidad del Rosario

Repositorio:

Repositorio EdocUR - U. Rosario

Idioma:

eng

OAI Identifier:

oai:repository.urosario.edu.co:10336/24222

Acceso en línea:

https://doi.org/10.1093/hmg/ddu106
https://repository.urosario.edu.co/handle/10336/24222

Palabra clave:

Alpha integrin
Cd11b antigen
Early b cell factor 1
Fibrinogen
Integrin alpha m
Ku antigen
Ku70/80
Nfkb1 protein
Nucleic acid
Protein
Rna
Transcription factor
Unclassified drug
Vitronectin
Cd11b antigen
Cell nucleus antigen
Chromatin
Dna binding protein
Fibrinogen
Immunoglobulin enhancer binding protein
Ku antigen
Messenger rna
Protein binding
Transactivator protein
Vitronectin
Allele
Ancestry group
Article
Chromatin
Gene function
Gene locus
Genetic analysis
Genetic association
Genetic predisposition
Genetic risk
Genetic variability
Genotype
Heterozygote
Human
In vitro study
In vivo study
Ligand binding
Meta analysis
Missense mutation
Monocyte
Priority journal
Protein binding
Protein expression
Rna degradation
Single nucleotide polymorphism
Systemic lupus erythematosus
Ethnology
Female
Gene expression regulation
Gene frequency
Genetic polymorphism
Genetic transcription
Genetics
Male
Metabolism
Pathology
Risk
Systemic lupus erythematosus
Alleles
Chromatin
Continental population groups
Dna-binding proteins
Female
Fibrinogen
Gene expression regulation
Gene frequency
Genetic predisposition to disease
Humans
Male
Monocytes
Nf-kappa b p50 subunit
Odds ratio
Protein binding
Risk
Trans-activators
Vitronectin
human
messenger
human
human
genetic
genetic
cd11b
nuclear
systemic
Ebf1 protein
Itgam protein
Nfkb1 protein
Antigens
Antigens
Lupus erythematosus
Polymorphism
Rna
Transcription

Rights

License

Abierto (Texto Completo)