Activation of the PI3K/AKT signalling pathway by insulin-like growth factor type II stimulates metalloproteinase 9 mRNA expression in choriocarcinoma cells

Metalloproteinases 2 and 9 (MMP-2 and MMP-9) and Tissue Inhibitor-1 of MMPs (TIMP-1) could contribute to regulate the invasive behaviour of trophoblastic cells, effect which could be mediated by Insulin- like growth factor type II (IGF-II), which regulates the development and function of trophoblast...