Transcriptional responses of Leishmania (Leishmania) amazonensis in the presence of trivalent sodium stibogluconate

Background: In the last decade, resistance to antimonials has become a serious problem due to the emergence of drug-resistant strains. Therefore, understanding the mechanisms used by Leishmania parasites to survive under drug pressure is essential, particularly for species of medical-veterinary impo...

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Autores:

Tipo de recurso:

Fecha de publicación:

2019

Institución:

Universidad del Rosario

Repositorio:

Repositorio EdocUR - U. Rosario

Idioma:

eng

OAI Identifier:

oai:repository.urosario.edu.co:10336/22752

Acceso en línea:

https://doi.org/10.1186/s13071-019-3603-8
https://repository.urosario.edu.co/handle/10336/22752

Palabra clave:

Antimony
Autophagy related protein
Stibogluconate sodium
Transcriptome
Antimony gluconate
Antiprotozoal agent
Protozoal dna
Transcriptome
Antiparasitic activity
Article
Autophagy
Cell cycle
Cell death
Controlled study
Cytoskeleton
Drug response
Fatty acid metabolism
Gene expression
Genetic code
Genetic identification
Leishmania
Leishmania amazonensis
Nonhuman
Parasite survival
Promastigote
Rna sequence
Stress
Transcriptomics
Upregulation
Drug effect
Drug resistance
Gene expression profiling
Gene ontology
Genetics
Phenotype
Sequence analysis
Antimony sodium gluconate
Antiprotozoal agents
Drug resistance
Gene expression profiling
Gene ontology
Leishmania
Phenotype
Transcriptome
Up-regulation
Deg
Diffuse leishmaniasis
Hierarchical cluster analysis (hca)
Principal components analysis (pca)
Resistance
Transcript
rna
protozoan
Dna
Sequence analysis

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Abierto (Texto Completo)