An Ultraconserved brain-specific enhancer within ADGRL3 (LPHN3) underpins attention-deficit/hyperactivity disorder susceptibility

BACKGROUND—Genetic factors predispose to attention deficit/hyperactivity disorder (ADHD). Previous studies have reported linkage and association to ADHD of gene variants within ADGRL3. In this study, we functionally analyzed non-coding variants in this gene as likely pathological contributors. METHO...

Full description

Autores:

Tipo de recurso:

Fecha de publicación:

2016

Institución:

Universidad del Rosario

Repositorio:

Repositorio EdocUR - U. Rosario

Idioma:

eng

OAI Identifier:

oai:repository.urosario.edu.co:10336/26069

Acceso en línea:

https://doi.org/10.1016/j.biopsych.2016.06.026
https://repository.urosario.edu.co/handle/10336/26069

Palabra clave:

ADHD
Genetics
ADGRL3
LPHN3
Latrophilin
Cis-acting regulatory element
Enhancer
Evolutionary conserved regions
Zebrafish

Rights

License

Abierto (Texto Completo)