The IRF5-TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share

Exploiting genotyping, DNA sequencing, imputation and trans-ancestral mapping, we used Bayesian and frequentist approaches to model the IRF5-TNPO3 locus association, now implicated in two immunotherapies and seven autoimmune diseases. Specifically, in systemic lupus erythematosus (SLE), we resolved...

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Autores:

Tipo de recurso:

Fecha de publicación:

2015

Institución:

Universidad del Rosario

Repositorio:

Repositorio EdocUR - U. Rosario

Idioma:

eng

OAI Identifier:

oai:repository.urosario.edu.co:10336/24223

Acceso en línea:

https://doi.org/10.1093/hmg/ddu455
https://repository.urosario.edu.co/handle/10336/24223

Palabra clave:

Transcription factor
Transcription factor zbtb3
Unclassified drug
Dna binding protein
Interferon regulatory factor
Karyopherin beta
Allele
Ancestry group
Article
Autoimmune disease
Bayes theorem
Controlled study
Disease assessment
Dna sequence
European
Gene
Gene expression
Gene locus
Gene mapping
Genetic association
Genetic variability
Genotype
Haplotype
Human
Irf5 gene
Major clinical study
Primary biliary cirrhosis
Priority journal
Promoter region
Sjoegren syndrome
Systemic lupus erythematosus
Systemic sclerosis
Tnpo3 gene
Autoimmune disease
Case control study
Cohort analysis
Genetics
Male
Single nucleotide polymorphism
Systemic lupus erythematosus
Autoimmune diseases
Bayes theorem
Beta karyopherins
Case-control studies
Cohort studies
Dna-binding proteins
Haplotypes
Humans
Interferon regulatory factors
Male
systemic
single nucleotide
human
human
human
genetic
Irf5 protein
Tnpo3 protein
Zbtb3 protein
Lupus erythematosus
Polymorphism
Promoter regions

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Abierto (Texto Completo)