Functionally relevant proteins in Plasmodium falciparum host cell invasion

A totally effective, antimalarial vaccine must involve sporozoite and merozoite proteins (or their fragments) to ensure complete parasite blocking during critical invasion stages. This Special Report examines proteins involved in critical biological functions for parasite survival and highlights the conserved amino acid sequences of the most important proteins involved in sporozoite invasion of hepatocytes and merozoite invasion of red blood cells. Conserved high activity binding peptides are located in such proteins' functionally strategic sites, whose functions are related to receptor binding, nutrient and protein transport, enzyme activity and molecule-molecule interactions. They are thus excellent targets for vaccine development as they block proteins binding function involved in invasion and also their biological function. © 2017 Future Medicine Ltd.

• Fecha de publicación: 2017
• Institución: Universidad del Rosario
• Repositorio: Repositorio EdocUR - U. Rosario
• Idioma: eng
• OAI Identifier: oai:repository.urosario.edu.co:10336/24286
• Acceso en línea: https://doi.org/10.2217/imt-2016-0091; https://repository.urosario.edu.co/handle/10336/24286
• Palabra clave: Apical membrane antigen 1; Cell transversal protein for ookinetes and spzs; Circumsporozoite protein 1; Erythrocyte binding antigen 140; Erythrocyte binding antigen 181; Erythrocyte binding antigen 75; Erythrocyte binding ligand; Erythrocyte binding ligand 1; Liver stage antigen 1; Liver stage antigen 3; Malaria vaccine; Merozoite apical erythrocyte binding ligand; Merozoite surface protein 1; Merozoite surface protein 10; Merozoite surface protein 2; Merozoite surface protein 4; Merozoite surface protein 7; Merozoite surface protein 9; Multidomain sporozoite surface protein 2; Parasite antigen; Serine repeat antigen 5; Sporozoite invasion associated protein 1; Sporozoite invasion associated protein 2; Sporozoite microneme protein essential for cell transversal 1; Sporozoite microneme protein essential for cell transversal 2; Sporozoite protein; Sporozoite threonine and asparagine rich protein; Thrombospondin related anonymous protein; Thrombospondin related sporozoite protein; Unclassified drug; Unindexed drug; Amino acid sequence; Cell invasion; Drug efficacy; Drug safety; Erythrocyte; Host parasite interaction; Human; Immunogenicity; Liver cell; Malaria; Merozoite; Nonhuman; Parasite immunity; Parasite survival; Plasmodium falciparum; Protein binding; Protein secondary structure; Protein structure; Protein tertiary structure; Review; Sporozoite; Vaccination; Animal; Drug design; Host pathogen interaction; Immunology; Malaria falciparum; Metabolism; Nuclear magnetic resonance spectroscopy; Parasitology; Plasmodium falciparum; X ray crystallography; Animals; Drug design; Erythrocytes; Hepatocytes; Host-pathogen interactions; Humans; Magnetic resonance spectroscopy; Malaria vaccines; Plasmodium falciparum; Chabp; Invasion-proteins; Malaria; Merozoite; Sporozoite; Vaccine; falciparum; protozoan; x-ray; Antigens; Crystallography; Malaria
• License: Abierto (Texto Completo)