The H3K9 methylation writer SETDB1 and its reader MPP8 cooperate to silence satellite DNA repeats in mouse embryonic stem cells

SETDB1 (SET Domain Bifurcated histone lysine methyltransferase 1) is a key lysine methyltransferase (KMT) required in embryonic stem cells (ESCs), where it silences transposable elements and DNA repeats via histone H3 lysine 9 tri-methylation (H3K9me3), independently of DNA methylation. The H3K9 met...

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Autores:

Tipo de recurso:

Fecha de publicación:

2019

Institución:

Universidad del Rosario

Repositorio:

Repositorio EdocUR - U. Rosario

Idioma:

eng

OAI Identifier:

oai:repository.urosario.edu.co:10336/24143

Acceso en línea:

https://doi.org/10.3390/genes10100750
https://repository.urosario.edu.co/handle/10336/24143

Palabra clave:

Histone H3
Histone lysine methyltransferase
M phase phosphoprotein 8
Phosphoprotein
Repetitive DNA
Satellite DNA
SET domain bifurcated histone lysine methyltransferase 1
Small interfering RNA
Unclassified drug
Histone
Histone lysine methyltransferase
Phosphoprotein
Protein binding
Satellite DNA
Animal cell
Article
Binding site
Biochemical analysis
Cell cycle M phase
Chromatin immunoprecipitation
Comparative study
Complex formation
Controlled study
Down regulation
Embryo
Gene
Gene control
Gene expression
Gene expression regulation
Gene function
Gene number
Gene silencing
Gene targeting
Genomics
Hela S3 cell line
Histone methylation
Immunoprecipitation
Long interspersed nuclear element
Loss of function mutation
Molecular genetics
Mouse
Mouse embryonic stem cell
MPP8 gene
Nonhuman
Protein processing
Protein protein interaction
RNA sequence
SETDB1 gene
Short interspersed nuclear element
Transcriptomics
Upregulation
Animal
Cell culture
Genetics
Hela cell line
Human
Metabolism
Mouse embryonic stem cell
Animals
Hela Cells
Histone-Lysine N-Methyltransferase
Histones
Humans
Mice
Mouse Embryonic Stem Cells
Phosphoproteins
Protein Binding
Histone lysine methylation
M-phase phosphoprotein 8
Satellite DNA repeats
SETDB1/KMT1E
Transcription
Cultured
mouse
mouse
Satellite
Mphosph8 protein
SETDB1 protein
Cells
DNA

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