Mutant GNLY is linked to Stevens–Johnson syndrome and toxic epidermal necrolysis

Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare severe cutaneous adverse reactions to drugs. Granulysin (GNLY) plays a key role in keratinocyte apoptosis during SJS/TEN pathophysiology. To determine if GNLY-encoding mutations might be related to the protein’s functional...

Full description

Autores:
Tipo de recurso:
Fecha de publicación:
2019
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/24215
Acceso en línea:
https://doi.org/10.1007/s00439-019-02066-w
https://repository.urosario.edu.co/handle/10336/24215
Palabra clave:
Carbamazepine
Cefalexin
Cocodamol
Contrast medium
Cotrimoxazole
Granulysin
Lamotrigine
Metoclopramide
Phenytoin
Pyrimethamine plus sulfadoxine
Sulfonamide
Biological marker
Mutant protein
T lymphocyte antigen
Adult
Animal cell
Article
Cellular distribution
Child
Cho cell line
Clinical article
Codon
Computer model
Female
Gene frequency
Gene mutation
Gene sequence
Heterozygote
Human
Male
Middle aged
Nonhuman
Nucleotide sequence
Pathogenesis
Pathophysiology
Preschool child
Priority journal
Protein localization
Sanger sequencing
School child
Stevens johnson syndrome
Toxic epidermal necrolysis
Urtica dioica
Western blotting
Young adult
Adolescent
Apoptosis
Case control study
Genetic predisposition
Genetics
Infant
Keratinocyte
Metabolism
Mutation
Necrosis
Pathology
Stevens johnson syndrome
Adolescent
Adult
Apoptosis
Biomarkers
Case-control studies
Child
Female
Genetic predisposition to disease
Humans
Infant
Keratinocytes
Male
Middle aged
Mutant proteins
Mutation
Necrosis
Stevens-johnson syndrome
Young adult
preschool
differentiation
human
t-lymphocyte
Gnly protein
Antigens
Child
Rights
License
Abierto (Texto Completo)