Towards a poly-functional synthetic-antimalarial vaccine: Incorporating non-natural elements into artificially-made peptides for mimicking functional pathogen ligand structures representing new site-directed vaccine components

The molecular basis for obtaining novel anti-malarial vaccine candidates depends on a considered selection of antigenic peptides, mainly derived from Plasmodium antigens' non-polymorphic regions. Since such targeted-molecules are poorly immunogenic when tested as vaccine components, they usually have to be modified to overcome their immunological phenotype. Transition state theory, explaining how peptidases catalyse a given peptide bond breakage, thus led to reduced amide pseudopeptides being proposed as possible mimetics for a transition-state. Stabilising such high-energy molecular stages could become a strategy for inducing antibodies potentially harbouring catalytic properties. Hence, isostere-bond peptido-mimetics represented a rational choice as potential abzyme-inducers and site-directed designed reduced amide pseudopeptides for obtaining peptide-analogues from selected malarial high-binding motifs. This novel family of vaccine candidates has proved to be an efficient functional antibody-inducer, the latter acting as efficient blockers of Plasmodium infection of human and mouse RBCs. © 2013 Bentham Science Publishers.

• Fecha de publicación: 2013
• Institución: Universidad del Rosario
• Repositorio: Repositorio EdocUR - U. Rosario
• Idioma: eng
• OAI Identifier: oai:repository.urosario.edu.co:10336/23810
• Acceso en línea: https://doi.org/10.2174/1573395510666140401180738; https://repository.urosario.edu.co/handle/10336/23810
• Palabra clave: Amide pseudopeptide; Epitope; Malaria vaccine; Merozoite surface protein 2; Parasite antibody; Peptide vaccine; Peptidomimetic agent; Pseudopeptide; Synthetic peptide; Unclassified drug; Antimalarial activity; Article; Erythrocyte; Human; Immune response; Immunogenicity; Immunoprophylaxis; In vitro study; Malaria; Malaria falciparum; Nonhuman; Parasitemia; Passive immunization; Phase transition; Plasmodium (life cycle stage); Plasmodium falciparum; Priority journal; Protein binding; Protein hydrolysis; Protein motif; Protein targeting; Public health problem; Rodent malaria; Vaccine production; Antimalarial vaccine; Catalytic antibody; Passive immunisation; Peptide-bond isostere; Peptido-mimetic; Pseudopeptide
• License: Abierto (Texto Completo)