Towards a poly-functional synthetic-antimalarial vaccine: Incorporating non-natural elements into artificially-made peptides for mimicking functional pathogen ligand structures representing new site-directed vaccine components

The molecular basis for obtaining novel anti-malarial vaccine candidates depends on a considered selection of antigenic peptides, mainly derived from Plasmodium antigens' non-polymorphic regions. Since such targeted-molecules are poorly immunogenic when tested as vaccine components, they usuall...

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Autores:

Tipo de recurso:

Fecha de publicación:

2013

Institución:

Universidad del Rosario

Repositorio:

Repositorio EdocUR - U. Rosario

Idioma:

eng

OAI Identifier:

oai:repository.urosario.edu.co:10336/23810

Acceso en línea:

https://doi.org/10.2174/1573395510666140401180738
https://repository.urosario.edu.co/handle/10336/23810

Palabra clave:

Amide pseudopeptide
Epitope
Malaria vaccine
Merozoite surface protein 2
Parasite antibody
Peptide vaccine
Peptidomimetic agent
Pseudopeptide
Synthetic peptide
Unclassified drug
Antimalarial activity
Article
Erythrocyte
Human
Immune response
Immunogenicity
Immunoprophylaxis
In vitro study
Malaria
Malaria falciparum
Nonhuman
Parasitemia
Passive immunization
Phase transition
Plasmodium (life cycle stage)
Plasmodium falciparum
Priority journal
Protein binding
Protein hydrolysis
Protein motif
Protein targeting
Public health problem
Rodent malaria
Vaccine production
Antimalarial vaccine
Catalytic antibody
Passive immunisation
Peptide-bond isostere
Peptido-mimetic
Pseudopeptide

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