DNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering
Accumulation of DNA lesions causing transcription stress is associated with natural and accelerated aging and culminates with profound metabolic alterations. Our understanding of the mechanisms governing metabolic redesign upon genomic instability, however, is highly rudimentary. Using Ercc1-defecti...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2019
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/22636
- Acceso en línea:
- https://doi.org/10.1038/s41467-019-12640-5
https://repository.urosario.edu.co/handle/10336/22636
- Palabra clave:
- 1 phosphofructokinase
Antimycin a1
Carbonyl cyanide 4 (trifluoromethoxy)phenylhydrazone
Glucose 6 phosphate dehydrogenase
Glucose transporter
Glutathione
Oligomycin
Pentose phosphate
Reduced nicotinamide adenine dinucleotide phosphate
Rotenone
Sugar phosphate
Adenosine triphosphate
Antioxidant
Dna binding protein
Dna excision repair protein ercc-5
Endonuclease
Nicotinamide adenine dinucleotide phosphate
Nuclear protein
Transcription factor
Aging
Antioxidant
Bioenergetics
Buffering
Dna
Enzyme activity
Metabolism
Phosphate
Redox conditions
Stress analysis
Ampk signaling
Animal experiment
Animal model
Antioxidant activity
Article
Bioenergy
Bioinformatics
Cell isolation
Cockayne syndrome
Cycloaddition
Dna damage
Dna repair
Dna transcription
Down regulation
Drug potentiation
Enzyme activity
Enzyme metabolism
Excision repair
Female
Flow cytometry
Gene expression level
Gene mutation
Genomic instability
Glycolysis
High performance liquid chromatography
Male
Metabolic activity assay
Metabolic flux analysis
Mitochondrial respiration
Mouse
Nonhuman
Nuclear reprogramming
Oxygen consumption
Pentose phosphate cycle
Peritoneum
Polymerase chain reaction
Protein phosphorylation
Redox stress
Rna isolation
Rna synthesis
Signal transduction
Skin biopsy
Skin fibroblast
Transcription coupled dna repair
Upregulation
Allosterism
Animal
Cytology
Dna damage
Fibroblast
Genetic transcription
Genetics
Knockout mouse
Metabolism
Metabolomics
Oxidation reduction reaction
Physiology
Skin
Animalia
Mus
Adenosine triphosphate
Allosteric regulation
Animals
Antioxidants
Cockayne syndrome
Dna damage
Dna repair
Dna-binding proteins
Endonucleases
Fibroblasts
Genomic instability
Glycolysis
Metabolomics
Mice
Nadp
Nuclear proteins
Oxidation-reduction
Pentose phosphate pathway
Skin
Transcription factors
knockout
mouse
genetic
Ercc1 protein
Mice
Transcription
- Rights
- License
- Abierto (Texto Completo)