Redefining an epitope of a malaria vaccine candidate, with antibodies against the N-terminal MSA-2 antigen of Plasmodium harboring non-natural peptide bonds

The aim of obtaining novel vaccine candidates against malaria and other transmissible diseases can be partly based on selecting non-polymorphic peptides from relevant antigens of pathogens, which have to be then precisely modified for inducing a protective immunity against the disease. Bearing in mi...

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Autores:
Tipo de recurso:
Fecha de publicación:
2013
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/24274
Acceso en línea:
https://doi.org/10.1007/s00726-013-1541-x
https://repository.urosario.edu.co/handle/10336/24274
Palabra clave:
Epitope
Immunoglobulin antibody
Immunoglobulin class
Malaria vaccine
Merozoite surface protein 2
Monoclonal antibody
Peptidomimetic agent
Polyclonal antibody
Animal cell
Animal experiment
Animal model
Aotus
Article
Bagg albino mouse
Bioinformatics
Chemical structure
Controlled study
Epitope mapping
Erythrocyte
Female
Infrared spectroscopy
Mouse
Nonhuman
Parasitemia
Passive immunization
Peptide synthesis
Plasmodium
Plasmodium berghei
Plasmodium berghei infection
Plasmodium falciparum
Plasmodium yoelii
Plasmodium yoelii infection
Priority journal
Proton nuclear magnetic resonance
Solid phase synthesis
Mus
Plasmodium falciparum
Rodentia
Antigen-antibody reactions
Computational biology
Epitopes
Malaria vaccines
Plasmodium falciparum
Protozoan proteins
Antibody
Malaria vaccine candidate
Passive immunization
Peptide mimetic
Peptide-bond isostere
Site-directed design
monoclonal
protozoan
Antibodies
Antigens
Rights
License
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