Influence of Variations in CCL3L1 and CCR5 on Tuberculosis in a Northwestern Colombian Population

We investigated the association of polymorphisms in CCR5, the major human immunodeficiency virus (HIV)-1 coreceptor, and copy number of its potent ligand CCL3L1 with tuberculosis in 298 individuals from Colombia. The CCR5-HHD haplotype, a known genetic determinant of increased susceptibility to HIV-AIDS, and a high copy number of CCL3L1, a known genetic determinant of enhanced CCL3/CCL3L1 chemokine expression, each associated with presence of tuberculosis. Furthermore, CCR5-HHD was associated with higher CCR5 gene and surface expression. These results substantiate the strong link between the proinflammatory effects of CCR5 and its ligands with active tuberculosis and suggest that chemokine-chemokine receptor genetic determinants may influence tuberculosis in addition to HIV/AIDS. © The Author 2011. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.

• Fecha de publicación: 2011
• Institución: Universidad del Rosario
• Repositorio: Repositorio EdocUR - U. Rosario
• Idioma: eng
• OAI Identifier: oai:repository.urosario.edu.co:10336/22374
• Acceso en línea: https://doi.org/10.1093/infdis/jir145; https://repository.urosario.edu.co/handle/10336/22374
• Palabra clave: CCL3L1 chemokine; Chemokine; Chemokine receptor CCR5; Macrophage inflammatory protein 1alpha; Membrane protein; Unclassified drug; Virus receptor; Acquired immune deficiency syndrome; Adult; Article; CCR5 gene; Colombia; Controlled study; DNA polymorphism; Female; Gene; Gene dosage; Genetic susceptibility; Genetic variability; Haplotype; Human; Human cell; Human immunodeficiency virus 1; Human immunodeficiency virus infection; Major clinical study; Male; Priority journal; Protein expression; Tuberculosis; Adult; Case-Control Studies; Colombia; Female; Gene Dosage; Haplotypes; Humans; Linkage Disequilibrium; Logistic Models; Male; Middle Aged; Tuberculosis; CCR5; Genetic; CC; Chemokines; Polymorphism; Receptors
• License: Abierto (Texto Completo)