BMP15 mutations associated with primary ovarian insufficiency reduce expression, activity, or synergy with gdf9

Context: Bone morphogenetic protein (BMP)15 is an oocyte-specific growth factor, which, together with growth differentiation factor (GDF) 9, regulates folliculogenesis and ovulation rate. Multiple mutations in BMP15 have been identified in women with primary ovarian insufficiency (POI), supporting a...

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Autores:

Tipo de recurso:

Fecha de publicación:

2017

Institución:

Universidad del Rosario

Repositorio:

Repositorio EdocUR - U. Rosario

Idioma:

eng

OAI Identifier:

oai:repository.urosario.edu.co:10336/22298

Acceso en línea:

https://doi.org/10.1210/jc.2016-3503
https://repository.urosario.edu.co/handle/10336/22298

Palabra clave:

Bone morphogenetic protein 15
Cysteine
Growth differentiation factor 9
Guanine
Histone
Tyrosine
Bone morphogenetic protein 15
Growth differentiation factor 9
Adult
Amino acid substitution
Article
Bmp15 gene
Cell activation
Controlled study
Down regulation
Female
Gene expression regulation
Gene function
Gene mutation
Gene sequence
Genetic association
Genetic variability
Granulosa cell
Human
Major clinical study
Mutational analysis
Premature ovarian failure
Protein function
Protein secondary structure
Protein secretion
Protein synthesis
Wild type
Drug effect
Gene expression
Genetics
Metabolism
Molecular model
Mutation
Premature ovarian failure
Reverse transcription polymerase chain reaction
Tumor cell line
Adult
Bone morphogenetic protein 15
Female
Gene expression
Granulosa cells
Growth differentiation factor 9
Humans
Mutation
Primary ovarian insufficiency
Reverse transcriptase polymerase chain reaction
molecular
human
human
tumor
Bmp15 protein
Gdf9 protein
Cell line
Models

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Abierto (Texto Completo)