Effect of low doses of estradiol and tamoxifen on breast cancer cell karyotypes

Evidence supports a role of 17?-estradiol (E2) in carcinogenesis and the large majority of breast carcinomas are dependent on estrogen. The anti-estrogen tamoxifen (TAM) is widely used for both treatment and prevention of breast cancer; however, it is also carcinogenic in human uterus and rat liver,...

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Autores:

Tipo de recurso:

Fecha de publicación:

2016

Institución:

Universidad del Rosario

Repositorio:

Repositorio EdocUR - U. Rosario

Idioma:

eng

OAI Identifier:

oai:repository.urosario.edu.co:10336/23922

Acceso en línea:

https://doi.org/10.1530/ERC-16-0078
https://repository.urosario.edu.co/handle/10336/23922

Palabra clave:

Epidermal growth factor receptor 2
Estradiol
Estrogen receptor
Progesterone receptor
Tamoxifen
Antiestrogen
Antineoplastic hormone agonists and antagonists
Estradiol
Tamoxifen
Article
Breast cancer cell line
Cell proliferation
Chromosome aberration
Chromosome rearrangement
Controlled study
Genotoxicity
Human
Human cell
In vitro study
Karyotype
Karyotyping
Low drug dose
Mcf 7 cell line
Treatment duration
Breast tumor
Chemically induced
Drug effects
Genetics
Karyotype
Tumor cell line
Breast neoplasms
Cell proliferation
Chromosome aberrations
Estradiol
Estrogen antagonists
Humans
Karyotype
Tamoxifen
Breast cancer cells
Chromosomal abnormalities
Chromosomal instability
Estradiol
Tamoxifen
tumor
hormonal
Antineoplastic agents
Cell line

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