Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice

Mice deficient in the DNA excision-repair gene Ercc1 (Ercc1?/-) show numerous accelerated ageing features that limit their lifespan to 4-6 months. They also exhibit a 'survival response', which suppresses growth and enhances cellular maintenance. Such a response resembles the anti-ageing r...

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Autores:

Tipo de recurso:

Fecha de publicación:

2016

Institución:

Universidad del Rosario

Repositorio:

Repositorio EdocUR - U. Rosario

Idioma:

eng

OAI Identifier:

oai:repository.urosario.edu.co:10336/22646

Acceso en línea:

https://doi.org/10.1038/nature19329
https://repository.urosario.edu.co/handle/10336/22646

Palabra clave:

Aging
Cells and cell components
Damage
Diet
Dna
Gene expression
Genome
Genomics
Rodent
Animalia
Mus
Dna binding protein
Dna excision repair protein ercc-5
Endonuclease
Nuclear protein
Transcription factor
Transcriptome
Aging
Animal
Brain
Caloric restriction
Deficiency
Dna damage
Dna repair
Female
Genetics
Genomic instability
Low calory diet
Male
Mouse
Neurodegenerative diseases
Physiology
Aging
Animals
Brain
Caloric restriction
Dna damage
Dna repair
Dna-binding proteins
Endonucleases
Female
Genomic instability
Male
Mice
Neurodegenerative diseases
Nuclear proteins
Transcription factors
Transcriptome
mouse
reducing
Ercc1 protein
Diet

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