The association of statins plus LDL receptor-targeted liposome-encapsulated doxorubicin increases in vitro drug delivery across blood-brain barrier cells

Background and PurposeThe passage of drugs across the blood-brain barrier (BBB) limits the efficacy of chemotherapy in brain tumours. For instance, the anticancer drug doxorubicin, which is effective against glioblastoma in vitro, has poor efficacy in vivo, because it is extruded by P-glycoprotein (...

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Autores:

Tipo de recurso:

Fecha de publicación:

2012

Institución:

Universidad del Rosario

Repositorio:

Repositorio EdocUR - U. Rosario

Idioma:

eng

OAI Identifier:

oai:repository.urosario.edu.co:10336/23615

Acceso en línea:

https://doi.org/10.1111/j.1476-5381.2012.02103.x
https://repository.urosario.edu.co/handle/10336/23615

Palabra clave:

Breast cancer resistance protein
Compactin
Doxorubicin
Immunoglobulin enhancer binding protein
Low density lipoprotein receptor
Multidrug resistance protein
Nanoparticle
Nitric oxide
Rho kinase
Rhoa guanine nucleotide binding protein
Rhoa kinase
Simvastatin
Unclassified drug
Article
Blood brain barrier
Brain cell
Controlled study
Drug cytotoxicity
Drug dosage form comparison
Drug efficacy
Drug mechanism
Drug penetration
Drug potentiation
Drug receptor binding
Drug transport
Enzyme activity
Glioblastoma
Human
Human cell
In vitro study
Liposomal delivery
Microvascular endothelial cell
Priority journal
Protein expression
Tumor cell line
Atp-binding cassette transporters
Blood-brain barrier
Cell line
Doxorubicin
Humans
Hydroxymethylglutaryl-coa reductase inhibitors
Liposomes
Lovastatin
Nf-kappa b
Nitric oxide synthase
Nitrites
Rho-associated kinases
Rhoa gtp-binding protein
Simvastatin
Atp-binding cassette transporters
Blood-brain barrier
Central nervous system tumours
Doxorubicin
Liposomes
Low-density lipoproteins receptor
Nitric oxide
Statins
ldl
tumor
Cell line
Receptors

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Abierto (Texto Completo)