X Chromosome Dose and Sex Bias in Autoimmune Diseases: Increased Prevalence of 47,XXX in Systemic Lupus Erythematosus and Sjögren's Syndrome

Objective More than 80% of autoimmune disease predominantly affects females, but the mechanism for this female bias is poorly understood. We suspected that an X chromosome dose effect accounts for this, and we undertook this study to test our hypothesis that trisomy X (47,XXX; occurring in ?1 in 1,0...

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Autores:

Tipo de recurso:

Fecha de publicación:

2016

Institución:

Universidad del Rosario

Repositorio:

Repositorio EdocUR - U. Rosario

Idioma:

eng

OAI Identifier:

oai:repository.urosario.edu.co:10336/23022

Acceso en línea:

https://doi.org/10.1002/art.39560
https://repository.urosario.edu.co/handle/10336/23022

Palabra clave:

Article
Autoimmune disease
Controlled study
Female
Fluorescence in situ hybridization
Gene dosage
Human
Live birth
Major clinical study
Polymerase chain reaction
Prevalence
Primary biliary cirrhosis
Priority journal
Quality control
Rheumatoid arthritis
Sarcoidosis
Sex
Single nucleotide polymorphism
Systemic lupus erythematosus
X chromosome
Autoimmune Diseases
Case control study
Sarcoidosis
Sex chromosome aberration
Sex Chromosome Disorders of Sex Development
Sex ratio
Sjogren's Syndrome
Trisomy
X chromosome
Autoimmune Diseases
Case-Control Studies
Female
Gene Dosage
Humans
Prevalence
Sarcoidosis
Sex Chromosome Aberrations
Sex Chromosome Disorders of Sex Development
Sex Distribution
Sjogren's Syndrome
Trisomy
Rheumatoid
Systemic
Rheumatoid
Fluorescence
Human
Biliary
Biliary
XXX
Systemic
X
Karyotype 47
Arthritis
Liver Cirrhosis
Lupus Erythematosus
Arthritis
Chromosomes
In Situ Hybridization
Liver Cirrhosis
Lupus Erythematosus

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