The impact of HIV-1 within-host evolution on transmission dynamics

The adaptive potential of HIV-1 is a vital mechanism to evade host immune responses and antiviral treatment. However, high evolutionary rates during persistent infection can impair transmission efficiency and alter disease progression in the new host, resulting in a delicate trade-off between within-host virulence and between-host infectiousness. This trade-off is visible in the disparity in evolutionary rates at within-host and between-host levels, and preferential transmission of ancestral donor viruses. Understanding the impact of within-host evolution for epidemiological studies is essential for the design of preventive and therapeutic measures. Herein, we review recent theoretical and experimental work that generated new insights into the complex link between within-host evolution and between-host fitness, revealing temporal and selective processes underlying the structure and dynamics of HIV-1 transmission. © 2017 Elsevier B.V.

• Fecha de publicación: 2018
• Institución: Universidad del Rosario
• Repositorio: Repositorio EdocUR - U. Rosario
• Idioma: eng
• OAI Identifier: oai:repository.urosario.edu.co:10336/23826
• Acceso en línea: https://doi.org/10.1016/j.coviro.2017.12.001; https://repository.urosario.edu.co/handle/10336/23826
• Palabra clave: Chemokine receptor CCR5; Chemokine receptor CXCR4; Bottleneck population; CD4 lymphocyte count; Disease course; Genetic distance; Genetic variability; Host pathogen interaction; Human; Human immunodeficiency virus 1; Molecular epidemiology; Molecular evolution; Nonhuman; Phylogeny; Priority journal; Review; Viral genetics; Virus load; Virus morphology; Virus transmission; Virus virulence; Epidemic; Genetics; Host pathogen interaction; Human immunodeficiency virus 1; Human immunodeficiency virus infection; Molecular evolution; Pathogenicity; Theoretical model; Transmission; Virulence; Epidemics; HIV Infections; HIV-1; Host-Pathogen Interactions; Humans; Virulence; Molecular; Theoretical; Evolution; Models
• License: Abierto (Texto Completo)